|  | ng of target DNA/μg vaginal genomic DNA (mean ± SD) | |||
---|---|---|---|---|---|
Woman N. | Time point | Lactobacillus | Bifidobacterium | Atopobium | Prevotella |
Probiotic (P) | Â | Â | Â | Â | Â |
1 | W33 | 2.4 × 101 ± 1.1 | 1.9 × 10-2 ± 7.4 × 10-3 | 3.6 ± 1.5 | 2.1 × 10-2 ± 1.0 × 10-2 |
 | W37 | 3.0 × 101 ± 3.1 | 3.1 × 10-2 ± 2.7 × 10-4 | 1.3 × 101 ± 6.8 | 9.1 × 10-2 ± 1.6 × 10-2 |
2 | W33 | 9.6 ± 8.7 × 10-1 | 3.1 × 10-2 ± 8.8 × 10-3 | 5.4 × 101 ± 7.4 | 1.4 × 10-1 ± 4.8 × 10-2 |
 | W37 | 5.9 × 10-1 ± 4.9 × 10-2 | 2.4 × 10-2 ± 1.2 × 10-2 | 2.4 × 101 ± 1.9 × 101 | 1.1 × 10-1 ± 1.1 × 10-2 |
3 | W33 | 2.4 × 101 ± 2.9 | 2.4 × 10-2 ± 4.2 × 10-3 | 1.1 × 101 ± 6.0 | 1.1 × 10-1 ± 7.7 × 10-3 |
 | W37 | 2.2 × 101 ± 2.4 | 3.0 × 10-2 ± 2.4 × 10-3 | 4.0 ± 2.3 | 5.2 × 10-2 ± 8.2 × 10-3 |
4 | W33 | 2.2 × 101 ± 2.0 | 6.8 × 10-2 ± 8.3 × 10-3 | 4.7 ± 1.9 | 7.3 × 10-2 ± 2.9 × 10-2 |
 | W37 | 1.5 × 101 ± 1.4 | 2.1 × 10-2 ± 7.2 × 10-3 | 5.2 ± 2.0 | 4.6 × 10-2 ± 9.5 × 10-3 |
5 | W33 | 2.5 × 101 ± 4.5 | 2.1 × 10-2 ± 3.4 × 10-3 | 1.2 × 101 ± 3.0 | 9.3 × 10-2 ± 8.3 × 10-3 |
 | W37 | 2.2 x 101 ± 4.5 | 1.4 x 10-2 ± 3.2 x 10-3 | 1.5 x 101 ± 1.9 | 3.0 x 10-2 ± 1.1 x 10-2 |
6 | W33 | 1.1 × 10-1 ± 3.4 × 10-3 | 7.1 × 10-2 ± 7.1 × 10-3 | 1.0 × 101 ± 4.1 | 1.2 × 10-1 ± 1.3 × 10-2 |
 | W37 | 2.2 ± 6.0 × 10-1 | 2.1 ± 1.7 × 10-1 | 2.4 × 101 ± 1.0 × 101 | 1.5 × 10-1 ± 1.2 × 10-2 |
7 | W33 | 4.1 × 101 ± 8.5 | 3.7 × 10-2 ± 5.4 × 10-3 | 2.9 × 101 ± 9.2 | 1.2 × 10-1 ± 2.1 × 10-2 |
 | W37 | 2.0 × 101 ± 2.6 | 1.7 × 10-2 ± 4.4 × 10-3 | 2.6 × 101 ± 7.7 | 1.1 × 10-1 ± 1.1 × 10-3 |
8 | W33 | 1.0 × 101 ± 1.7 × 10-1 | 1.3 × 10-2 ± 1.9 × 10-3 | 5.5 ± 1.2 | 4.2 × 10-2 ± 1.9 × 10-2 |
 | W37 | 2.1 × 101 ± 2.0 | 1.5 × 10-2 ± 2.6 × 10-3 | 1.6 × 101 ± 6.6 | 5.1 × 10-2 ± 3.3 × 10-3 |
9 | W33 | 0.0 ± 0.0 | 7.1 × 10-3 ± 2.8 × 10-5 | 1.8 × 101 ± 7.1 | 6.7 × 10-2 ± 1.5 × 10-2 |
 | W37 | 0.0 ± 0.0 | 1.1 × 101 ± 1.0 | 1.5 × 101 ± 6.8 | 2.3 × 10-1 ± 8.0 × 10-2 |
10 | W33 | 6.7 ± 6.1 × 10-1 | 2.0 × 10-2 ± 4.8 × 10-3 | 1.4 × 101 ± 4.3 | 8.6 × 10-2 ± 2.0 × 10-2 |
 | W37 | 1.1 × 101 ± 1.4 | 2.3 × 10-2 ± 1.5 × 10-2 | 1.7 × 101 ± 9.7 | 8.0 × 10-2 ± 2.9 × 10-2 |
11 | W33 | 2.7 × 101 ± 1.7 | 2.9 x 10-3 ± 1.7 × 10-3 | 2.3 ± 1.8 | 3.2 × 10-2 ± 3.3 × 10-3 |
 | W37 | 3.0 × 101 ± 5.6 | 1.3 x 10-2 ± 8.5 × 10-3 | 1.3 ± 7.5 × 10-1 | 3.6 × 10-2 ± 1.3 × 10-2 |
12 | W33 | 2.2 ± 5.6 × 10-1 | 1.5 × 101 ± 2.3 | 1.4 × 101 ± 2.9 | 2.2 × 10-1 ± 2.1 × 10-2 |
 | W37 | 2.0 ± 3.1 × 10-1 | 8.7 ± 5.6 × 10-1 | 1.2 × 101 ± 2.3 | 1.0 × 10-1 ± 1.8 × 10-2 |
13 | W33 | 3.7 × 101 ± 5.4 | 3.0 × 10-2 ± 4.5 × 10-3 | 7.0 ± 2.6 × 10-1 | 2.7 × 10-2 ± 5.0 × 10-4 |
 | W37 | 6.6 × 101 ± 5.9 | 1.1 × 10-2 ± 2.2 × 10-3 | 6.8 ± 6.6 × 10-1 | 5.7 × 10-2 ± 2.0 × 10-3 |
14 | W33 | 2.2 × 101 ± 8.5 | 1.7 × 10-2 ± 4.9 × 10-3 | 9.0 ± 4.4 × 10-1 | 6.7 × 10-2 ± 6.6 × 10-3 |
 | W37 | 1.6 × 101 ± 4.9 | 2.8 × 10-2 ± 4.7 × 10-3 | 1.1 × 101 ± 1.1 | 1.1 × 10-1 ± 1.8 × 10-3 |
15 | W33 | 2.2 × 101 ± 7.1 | 1.4 × 10-2 ± 7.1 × 10-3 | 1.8 × 101 ± 5.6 | 1.1 × 10-1 ± 1.4 × 10-2 |
 | W37 | 2.8 × 101 ± 3.4 | 4.7 × 10-3 ± 2.3 × 10-3 | 1.1 × 101 ± 2.4 × 10-1 | 7.4 × 10-2 ± 2.4 × 10-3 |
Control (C) | Â | Â | Â | Â | Â |
16 | W33 | 5.4 × 101 ± 4.0 | 2.1 × 10-2 ± 5.6 × 10-3 | 1.1 × 101 ± 4.6 | 6.8 × 10-2 ± 1.1 × 10-2 |
 | W37 | 2.0 × 101 ± 1.7 | 2.0 × 10-2 ± 7.4 × 10-3 | 1.4 × 101 ± 5.0 | 5.6 × 10-2 ± 5.4 × 10-3 |
17 | W33 | 5.5 ± 5.3 × 10-1 | 6.0 ± 1.6 × 10-1 | 1.2 × 101 ± 4.3 | 5.9 × 10-2 ± 2.3 × 10-2 |
 | W37 | 1.5 × 101 ± 2.9 | 9.3 ± 5.3 × 10-1 | 1.9 × 101 ± 8.7 | 5.4 × 10-2 ± 1.0 × 10-2 |
18 | W33 | 2.6 ± 1.6 × 10-1 | 1.8 ± 3.5 × 10-2 | 1.3 × 101 ± 5.5 | 8.8 × 10-2 ± 1.7 × 10-2 |
 | W37 | 1.2 × 101 ± 2.0 | 2.9 ± 7.5 × 10-2 | 3.3 × 101 ± 4.4 | 4.5 × 10-2 ± 2.8 × 10-3 |
19 | W33 | 7.6 × 101 ± 3.3 × 10-1 | 1.2 ± 7.9 × 10-3 | 1.3 × 101 ± 3.6 | 1.9 × 10-1 ± 3.2 × 10-3 |
 | W37 | 2.7 × 101 ± 3.8 | 2.7 × 10-2 ± 4.7 × 10-3 | 8.2 ± 4.6 | 1.1 × 10-1 ± 2.6 × 10-2 |
20 | W33 | 1.6 × 101 ± 1.4 | 1.1 × 101 ± 1.2 | 1.2 × 101 ± 5.5 | 8.6 × 10-2 ± 1.5 × 10-2 |
 | W37 | 1.0 × 101 ± 6.4 × 10-2 | 1.1 × 101 ± 1.4 | 1.2 × 101 ± 4.7 | 1.1 × 10-1 ± 3.1 × 10-2 |
21 | W33 | 5.6 × 101 ± 8.3 | 1.7 × 10-2 ± 1.7 × 10-3 | 2.1 × 101 ± 1.0 × 101 | 1.3 × 10-1 ± 2.0 × 10-2 |
 | W37 | 6.4 × 101 ± 1.5 | 3.3 × 10-2 ± 8.7 × 10-3 | 2.2 × 101 ± 1.0 × 101 | 1.2 × 10-1 ± 2.4 × 10-2 |
22 | W33 | 4.3 × 101 ± 2.0 | 1.2 × 10-1 ± 2.8 × 10-2 | 2.3 × 10-1 ± 1.5 × 10-2 | 0.0 ± 0.0 |
 | W37 | 6.8 × 101 ± 5.1 | 2.7 × 10-2 ± 6.6 × 10-3 | 1.9 × 10-1 ± 2.0 × 10-2 | 0.0 ± 0.0 |
23 | W33 | 2.6 × 101 ± 5.6 | 2.3 × 10-1 ± 3.6 × 10-2 | 0.0 ± 0.0 | 0.0 ± 0.0 |
 | W37 | 6.3 × 101 ± 2.0 | 8.2 × 10-3 ± 1.9 × 10-3 | 1.6 × 10-1 ± 2.9 × 10-2 | 5.3 × 10-1 ± 1.8 × 10-1 |
24 | W33 | 1.2 × 101 ± 1.0 | 2.7 × 101 ± 2.1 × 10-1 | 1.8 ± 1.5 × 10-1 | 6.8 × 10-1 ± 3.4 × 10-2 |
 | W37 | 7.5 × 101 ± 3.8 | 9.7 × 10-3 ± 3.7 × 10-3 | 3.7 × 10-1 ± 3.4 × 10-2 | 0.0 ± 0.0 |
25 | W33 | 6.5 × 101 ± 1.0 × 101 | 3.0 × 10-2 ± 1.0 × 10-2 | 7.5 × 10-2 ± 7.5 × 10-3 | 0.0 ± 0.0 |
 | W37 | 6.6 × 101 ± 7.1 | 9.1 × 10-3 ± 5.1 × 10-4 | 2.5 × 10-1 ± 2.7 × 10-2 | 0.0 ± 0.0 |
26 | W33 | 8.5 × 101 ± 6.3 | 4.4 ± 9.3 × 10-1 | 3.2 × 10-1 ± 3.9 × 10-2 | 0.0 ± 0.0 |
 | W37 | 5.4 × 101 ± 4.5 | 2.0 × 10-2 ± 6.1 × 10-4 | 3.6 × 10-1 ± 4.2 × 10-2 | 0.0 ± 0.0 |
27 | W33 | 7.0 × 101 ± 1.5 × 101 | 3.3 × 10-2 ± 4.7 × 10-3 | 2.8 × 10-1 ± 2.6 × 10-2 | 0.0 ± 0.0 |
 | W37 | 6.6 × 101 ± 3.6 × 10-1 | 2.1 × 10-2 ± 1.6 × 10-2 | 4.0 × 10-1 ± 3.8 × 10-2 | 0.0 ± 0.0 |