Direct protein interaction network constructed from the genes differentially expressed with a fold change ≥ 2 or ≤ -2 (log
fold change ≥ 1 or ≤ -1, respectively) between DBA/2 and C57BL/6 mice at day 14 following C. immitis infection (N = 416). MetaCore was used to identify protein-protein and protein-DNA interactions between the protein products of differentially expressed genes and Cytoscape was used to visualize the network. Log2 fold changes were superimposed on this protein network such that red indicates greater expression in DBA/2 versus C57BL/6 mice, and blue lesser expression, as indicated by the scale bar. Each node represents a gene and the size of a node is indicative of the number of interactions the product of each gene makes at the protein level. The largest nodes are labeled HIF1A, IRF1, STAT1 and YY1, and represent hubs that correspond to transcription factors.