Hierarchical clustering of urine microbiomes. Heat map showing the relative abundance of bacterial genera across the urine samples. Genera are listed to the right. Subjects are listed at the top: interstitial cystitis (IC) samples denoted as P_number_V1V2 or V6, and healthy female (HF) urine samples as F_number_V1V2 or V6. Pink indicates IC urine, green HF urine. Color intensity of the heat map is directly proportional to log 10 scale of the abundance normalized sequence data as done by MEGAN V3.4. Taxa marked with (*) are genera that were significantly (p ≤ 0.05, p value from Metastats) different between the IC and HF urine microbiota. Genera marked with (†) and (§) are unique for HF urine sequences and IC urine sequences, respectively. Note that most of the IC urine samples are less complex than what is seen for HF urine samples.