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Table 1 Anti-pseudomonal agents in vitro activity against P. aeruginosa (n = 64) in planktonic and in biofilm conditions

From: Macrolides decrease the minimal inhibitory concentration of anti-pseudomonal agents against Pseudomonas aeruginosa from cystic fibrosis patients in biofilm

Antimicrobial Agent

Range MIC/ BIC

No. of isolates inhibited by different MIC/BIC values (mg/L) (n=64)

MIC50/ BIC50(mg/L)

MIC90/ BIC90(mg/L)

P value

  

≤0.5

1

2

4

8

16

32

64

128

≥256

   

CAZ

0.5-256/ 0.5-256

3/5

16/10

22/11

8/1

6/3

3/6

2/4

3/4

0/4

1/12

2/8

16/256

<0.001

CIP

0.5-128/ 0.5-256

42/31

3/10

7/4

2/2

1/3

5/3

3/4

0/4

1/1

0/2

0.5/1

16/64

0.016

TOB

0.5-256/ 0.5-256

9/4

17/6

18/13

7/11

1/7

1/10

1/4

3/4

0/1

7/4

2/4

64/64

0.008

IPM

0.5-128/ 0.5-256

21/8

17/1

6/2

5/9

7/6

6/11

1/6

0/5

1/5

0/11

1/16

16/256

<0.001

MEM

0.5-64/ 0.5-256

38/21

7/0

7/18

6/7

4/10

0/0

1/2

1/0

0/1

0/5

0.5/2

4/32

<0.001

  1. Detailed legend: CAZ - ceftazidime, CIP - ciprofloxacin, TOB - tobramycin, IPM - imipenem, MEM - meropenem, P – statistical significance (< 0.05), MIC – minimal inhibitory concentration, BIC – biofilm inhibitory concentration.
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BMC Microbiology

ISSN: 1471-2180

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