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Table 1 Anti-pseudomonal agents in vitro activity against P. aeruginosa (n = 64) in planktonic and in biofilm conditions

From: Macrolides decrease the minimal inhibitory concentration of anti-pseudomonal agents against Pseudomonas aeruginosa from cystic fibrosis patients in biofilm

Antimicrobial Agent Range MIC/ BIC No. of isolates inhibited by different MIC/BIC values (mg/L) (n=64) MIC50/ BIC50(mg/L) MIC90/ BIC90(mg/L) P value
   ≤0.5 1 2 4 8 16 32 64 128 ≥256    
CAZ 0.5-256/ 0.5-256 3/5 16/10 22/11 8/1 6/3 3/6 2/4 3/4 0/4 1/12 2/8 16/256 <0.001
CIP 0.5-128/ 0.5-256 42/31 3/10 7/4 2/2 1/3 5/3 3/4 0/4 1/1 0/2 0.5/1 16/64 0.016
TOB 0.5-256/ 0.5-256 9/4 17/6 18/13 7/11 1/7 1/10 1/4 3/4 0/1 7/4 2/4 64/64 0.008
IPM 0.5-128/ 0.5-256 21/8 17/1 6/2 5/9 7/6 6/11 1/6 0/5 1/5 0/11 1/16 16/256 <0.001
MEM 0.5-64/ 0.5-256 38/21 7/0 7/18 6/7 4/10 0/0 1/2 1/0 0/1 0/5 0.5/2 4/32 <0.001
  1. Detailed legend: CAZ - ceftazidime, CIP - ciprofloxacin, TOB - tobramycin, IPM - imipenem, MEM - meropenem, P – statistical significance (< 0.05), MIC – minimal inhibitory concentration, BIC – biofilm inhibitory concentration.