Figure 2

Inhibitory Quotient (IQ) of combinations of macrolide antibiotics to anti-pseudomonal agents against P. aeruginosa isolates. Detailed legend: CAZ 2AZM – ceftazidime with 2 mg/L of azithromycin, CAZ 8AZM - ceftazidime with 8 mg/L of azithromycin, CAZ 2CLR - ceftazidime with 2 mg/L of clarithromycin, CAZ 8CLR - ceftazidime with 8 mg/L of clarithromycin, CIP 2AZM – ciprofloxacin with 2 mg/L of azithromycin, CIP 8AZM - ciprofloxacin with 8 mg/L of azithromycin, CIP 2CLR - ciprofloxacin with 2 mg/L of clarithromycin, CIP 8CLR - ciprofloxacin with 8 mg/L of clarithromycin, TOB 2AZM – tobramycin with 2 mg/L of azithromycin, TOB 8AZM - tobramycin with 8 mg/L of azithromycin, TOB 2CLR - tobramycin with 2 mg/L of clarithromycin, TOB 8CLR - with 8 mg/L of clarithromycin, IPM 2AZM – imipenem with 2 mg/L of azithromycin, IPM 8AZM - imipenem with 8 mg/L of azithromycin, IPM 2CLR - imipenem with 2 mg/L of clarithromycin, IPM 8CLR - imipenem with 8 mg/L of clarithromycin, MEM 2AZM – meropenem with 2 mg/L of azithromycin, MEM 8AZM – meropenem with 8 mg/L of azithromycin, MEM 2CLR – meropenem with 2 mg/L of clarithromycin, MEM 8CLR – meropenem with 8 mg/L of clarithromycin. STRONG IQ (Black bar) means that there was a reduction in biofilm inhibitory concentration (BIC) when macrolides combination was tested and the isolates changed its profile from “Resistant” to “Susceptible”; WEAK IQ (Grey bar) means that there was a reduction in BIC value when the isolate profile changed from “Resistant” to “Intermediate”.