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Table 1 Result of homology based clustering analysis for 280 known type II PKSs

From: PKMiner: a database for exploring type II polyketide synthases

Domain Subfamily Biosynthetic function Number of domains in each subfamily Total number of domains Average length
KS a Keto synthase 43 43 416
CLF a Chain length factor 43 43 407
ACP a Acyl carrier protein 44 44 78
KR a C9 ketoredution 25 30 214
  b C7 ketoredution 5   204
ARO a First and second ring cyclization in reduced chain of Ben, Ang, Tet and Ant 28 67 132
  b First and second ring cyclization in reduced chain of Ben, Ang, Tet and Ant 28   143
  c First and second ring cyclization in unreduced chain of Pen and Tet 11   134
CYC a Second and third ring cyclization in Pen and Tet 11 57 93
  b Second and third ring cyclization in Aur and Ant 10   235
  c Final cyclization in Ang, Pen and Tet 19   102
  d Final cyclization in Ben 6   176
  e Final cyclization in Aur 5   121
  f Final cyclization in Ant 6   127
KSIII a Keto synthase III 4 7 218
  b Keto synthase III 3   231
AL a Acyl-CoA ligase 3 3 389
AT a Acyl transferase 10 10 320
MCAT a Malonyl-CoA: ACP transferase 3 3 309
TE a Thioesterase 1 1 232
  1. Unc-unclassified, Ang-Angucyclines, Ant-Anthracyclines, Ben- Benzoisochromanequinones, Pen- Pentangular polyphenols, Tet- Tetracenomycins, Aur- Tetracyclines/aureolic acids.
  2. For each of type II PKS domain, this table shows the subfamily, biosynthetic function, number of domains in each subfamily, total number of domains and the average length present in 280 known type II PKSs.