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Table 1 Result of homology based clustering analysis for 280 known type II PKSs

From: PKMiner: a database for exploring type II polyketide synthases

Domain

Subfamily

Biosynthetic function

Number of domains in each subfamily

Total number of domains

Average length

KS

a

Keto synthase

43

43

416

CLF

a

Chain length factor

43

43

407

ACP

a

Acyl carrier protein

44

44

78

KR

a

C9 ketoredution

25

30

214

 

b

C7 ketoredution

5

 

204

ARO

a

First and second ring cyclization in reduced chain of Ben, Ang, Tet and Ant

28

67

132

 

b

First and second ring cyclization in reduced chain of Ben, Ang, Tet and Ant

28

 

143

 

c

First and second ring cyclization in unreduced chain of Pen and Tet

11

 

134

CYC

a

Second and third ring cyclization in Pen and Tet

11

57

93

 

b

Second and third ring cyclization in Aur and Ant

10

 

235

 

c

Final cyclization in Ang, Pen and Tet

19

 

102

 

d

Final cyclization in Ben

6

 

176

 

e

Final cyclization in Aur

5

 

121

 

f

Final cyclization in Ant

6

 

127

KSIII

a

Keto synthase III

4

7

218

 

b

Keto synthase III

3

 

231

AL

a

Acyl-CoA ligase

3

3

389

AT

a

Acyl transferase

10

10

320

MCAT

a

Malonyl-CoA: ACP transferase

3

3

309

TE

a

Thioesterase

1

1

232

  1. Unc-unclassified, Ang-Angucyclines, Ant-Anthracyclines, Ben- Benzoisochromanequinones, Pen- Pentangular polyphenols, Tet- Tetracenomycins, Aur- Tetracyclines/aureolic acids.
  2. For each of type II PKS domain, this table shows the subfamily, biosynthetic function, number of domains in each subfamily, total number of domains and the average length present in 280 known type II PKSs.