From: PKMiner: a database for exploring type II polyketide synthases
Domain | Subfamily | Biosynthetic function | Number of domains in each subfamily | Total number of domains | Average length |
---|---|---|---|---|---|
KS | a | Keto synthase | 43 | 43 | 416 |
CLF | a | Chain length factor | 43 | 43 | 407 |
ACP | a | Acyl carrier protein | 44 | 44 | 78 |
KR | a | C9 ketoredution | 25 | 30 | 214 |
 | b | C7 ketoredution | 5 |  | 204 |
ARO | a | First and second ring cyclization in reduced chain of Ben, Ang, Tet and Ant | 28 | 67 | 132 |
 | b | First and second ring cyclization in reduced chain of Ben, Ang, Tet and Ant | 28 |  | 143 |
 | c | First and second ring cyclization in unreduced chain of Pen and Tet | 11 |  | 134 |
CYC | a | Second and third ring cyclization in Pen and Tet | 11 | 57 | 93 |
 | b | Second and third ring cyclization in Aur and Ant | 10 |  | 235 |
 | c | Final cyclization in Ang, Pen and Tet | 19 |  | 102 |
 | d | Final cyclization in Ben | 6 |  | 176 |
 | e | Final cyclization in Aur | 5 |  | 121 |
 | f | Final cyclization in Ant | 6 |  | 127 |
KSIII | a | Keto synthase III | 4 | 7 | 218 |
 | b | Keto synthase III | 3 |  | 231 |
AL | a | Acyl-CoA ligase | 3 | 3 | 389 |
AT | a | Acyl transferase | 10 | 10 | 320 |
MCAT | a | Malonyl-CoA: ACP transferase | 3 | 3 | 309 |
TE | a | Thioesterase | 1 | 1 | 232 |