Table 1  L. interrogans  encodes a complete pathway for legionaminic acid synthesis
From: Expression of sialic acids and other nonulosonic acids in Leptospira
 Campylobacter enzymes for legionaminic acid biosynthesis[14, 17–21] |  C. jejuni Pathway number (Figure 5) |  L. interrogans L1-130 & 56601 NCBI accession numbers | Predicted L. interrogans Pathway number (Figure 5) | Predicted enzymatic Function |
|---|---|---|---|---|
PmtE (cj1329) | 1 | YP_002106 | 1 | Glc-1-P guanyltransferase |
| Â | Â | NP_711792 | Â | Â |
GlmU | 2 | YP_000413 | 2 | (housekeeping) |
| Â | Â | NP_714003 | Â | N-acetyltransferase |
LegB (cj 1319) | 3 | YP_002111 | 3 | 4,6-dehydratase |
| Â | Â | NP_711787 | Â | Â |
LegC (cj1320) | 4 | YP_002110 | 4 | Aminotransferase in legionaminic acid synthesis (Figure 6A) |
| Â | Â | NP_711788 | Â | Â |
| Â | Â | YP_002103 | 4, 13, or ? | Aminotransferase |
| Â | Â | NP_711795 | Â | Â |
LegH (cj1298) | 5 | YP_002109 | 5 | N-acetyltransferase |
| Â | Â | NP_711789 | Â | Â |
LegG (cj1328) | 6 | YP_002107 | 6 | 2-epimerase/NDP sugar hydrolase in legionamimic acid synthesis |
| Â | Â | NP_711791 | Â | Â |
LegI (cj1327) | 7 | YP_002108 | 7 | Legionaminic acid synthase (Figure 6B) |
| Â | Â | NP_711790 | Â | Â |
| Â | Â | YP_002104 | 10 | Legionaminic or neuraminic acid synthase (Figures 6B & 7) |
| Â | Â | NP_711794 | Â | Â |
LegF (cj1331) | 8 | YP_002102 | 8 or 11 | CMP-Legionaminic acid or neuraminic acid synthetases (Figure 6C) |
| Â | Â | NP_711796 | Â | Â |
| Â | Â | YP_002112 | 8 or 11 | Â |
| Â | Â | NP_711786 | Â | Â |