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Table 1  L. interrogans  encodes a complete pathway for legionaminic acid synthesis

From: Expression of sialic acids and other nonulosonic acids in Leptospira

 Campylobacter enzymes for legionaminic acid biosynthesis[14, 1721]  C. jejuni Pathway number (Figure 5)  L. interrogans L1-130 & 56601 NCBI accession numbers Predicted L. interrogans Pathway number (Figure 5) Predicted enzymatic Function
PmtE (cj1329) 1 YP_002106 1 Glc-1-P guanyltransferase
   NP_711792   
GlmU 2 YP_000413 2 (housekeeping)
   NP_714003   N-acetyltransferase
LegB (cj 1319) 3 YP_002111 3 4,6-dehydratase
   NP_711787   
LegC (cj1320) 4 YP_002110 4 Aminotransferase in legionaminic acid synthesis (Figure 6A)
   NP_711788   
   YP_002103 4, 13, or ? Aminotransferase
   NP_711795   
LegH (cj1298) 5 YP_002109 5 N-acetyltransferase
   NP_711789   
LegG (cj1328) 6 YP_002107 6 2-epimerase/NDP sugar hydrolase in legionamimic acid synthesis
   NP_711791   
LegI (cj1327) 7 YP_002108 7 Legionaminic acid synthase (Figure 6B)
   NP_711790   
   YP_002104 10 Legionaminic or neuraminic acid synthase (Figures 6B & 7)
   NP_711794   
LegF (cj1331) 8 YP_002102 8 or 11 CMP-Legionaminic acid or neuraminic acid synthetases (Figure 6C)
   NP_711796   
   YP_002112 8 or 11  
   NP_711786