Table 1 In vitro activity of BMAP-27, BMAP-28, P19(9/B), and Tobramycin against P. aeruginosa, S. maltophilia and S. aureus CF strains

P. aeruginosa (25)

MIC₅₀^a

8

16

8

16

MIC₉₀^b

16

32

32

>64

MIC_range

4-16

4–32

4–32

2- > 64

MBC₅₀^c

8

16

16

32

MBC₉₀^d

16

32

64

>64

MBC_range

4–16

4–64

4- > 64

2- > 64

MBC/MIC

1.3

1.2

1.9^e

1.5^f

S. maltophilia (27)

MIC₅₀^a

4

4

4

>64

MIC₉₀^b

8

4

16

>64

MIC_range

4-8

2–8

4–32

4- > 64

MBC₅₀^c

8

4

8

>64

MBC₉₀^d

16

8

32

>64

MBC_range

4–32

2–16

4–64

8- > 64

MBC/MIC

1.9

1.3

1.7

1.3^g

S. aureus (15)

MIC₅₀^a

64

8

64

>64

MIC₉₀^b

>64

32

>64

>64

MIC_range

32- > 64

4–32

32- > 64

4- > 64

MBC₅₀^c

>64

8

>64

>64

MBC₉₀^d

>64

32

>64

>64

MBC_range

64- > 64

4–32

32- > 64

4- > 64

MBC/MIC

1.2^h

1.2

1.2ⁱ

1.0^l

Total (67)

MIC₅₀^a

8

4

8

>64

MIC₉₀^b

>64

16

64

>64

MIC_range

4->64

2–32

4- > 64

2- > 64

MBC₅₀^c

8

8

16

>64

MBC₉₀^d

>64

16

>64

>64

MBC_range

4- > 64

2–64

4- > 64

2- > 64

MBC/MIC

1.5^m

1.2

1.7ⁿ

1.4^o