Comparison of the homologous epa- like loci of E. faecium TX16 and E. faecalis OG1RF. Orthologs of epaP and epaQ, located at different positions in the E. faecium and E. faecalis genomes, are indicated by black arrows. Genes epaI, epaJ and epaK, present only in E. faecalis, are indicated by light grey arrows. The epaN homolog of E. faecium, which is shorter than epaN of E. faecalis, is shown by a dark grey arrow. The TX16 ORF (HMPREF0351_10906) with relatively low similarity to the β-lactamase superfamily is shown by a hatched arrow. The epaA to epaR region of E. faecium TX16 corresponds to locus tags HMPREF0351_10891 to HMPREF0351_10907.