TY - JOUR AU - Pepin, J. AU - Valiquette, L. AU - Cossette, B. PY - 2005 DA - 2005// TI - Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec JO - CMAJ VL - 173 UR - https://doi.org/10.1503/cmaj.050978 DO - 10.1503/cmaj.050978 ID - Pepin2005 ER - TY - JOUR AU - Goorhuis, A. AU - Debast, S. B. AU - van Leengoed, L. A. AU - Harmanus, C. AU - Notermans, D. W. AU - Bergwerff, A. A. PY - 2008 DA - 2008// TI - Clostridium difficile PCR ribotype 078: an emerging strain in humans and in pigs? JO - J Clin Microbiol VL - 46 UR - https://doi.org/10.1128/JCM.01536-07 DO - 10.1128/JCM.01536-07 ID - Goorhuis2008 ER - TY - JOUR AU - Goorhuis, A. AU - Bakker, D. AU - Corver, J. AU - Debast, S. B. AU - Harmanus, C. AU - Notermans, D. W. PY - 2008 DA - 2008// TI - Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction Type 078 JO - Clin Infect Dis VL - 47 UR - https://doi.org/10.1086/592257 DO - 10.1086/592257 ID - Goorhuis2008 ER - TY - JOUR AU - Debast, S. B. AU - van Leengoed, L. A. AU - Goorhuis, A. AU - Harmanus, C. AU - Kuijper, E. J. AU - Bergwerff, A. A. PY - 2009 DA - 2009// TI - Clostridium difficile PCR ribotype 078 toxinoType V found in diarrhoeal pigs identical to isolates from affected humans JO - Environ Microbiol VL - 11 UR - https://doi.org/10.1111/j.1462-2920.2008.01790.x DO - 10.1111/j.1462-2920.2008.01790.x ID - Debast2009 ER - TY - JOUR AU - He, M. AU - Sebaihia, M. AU - Lawley, T. D. AU - Stabler, R. A. AU - Dawson, L. F. AU - Martin, M. J. PY - 2010 DA - 2010// TI - Evolutionary dynamics of Clostridium difficile over short and long time scales JO - Proc Natl Acad Sci USA VL - 107 UR - https://doi.org/10.1073/pnas.0914322107 DO - 10.1073/pnas.0914322107 ID - He2010 ER - TY - JOUR AU - Stabler, R. A. AU - He, M. AU - Dawson, L. AU - Martin, M. AU - Valiente, E. AU - Corton, C. PY - 2009 DA - 2009// TI - Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium JO - Genome Biol VL - 10 UR - https://doi.org/10.1186/gb-2009-10-9-r102 DO - 10.1186/gb-2009-10-9-r102 ID - Stabler2009 ER - TY - JOUR AU - Sebaihia, M. AU - Wren, B. W. AU - Mullany, P. AU - Fairweather, N. F. AU - Minton, N. AU - Stabler, R. PY - 2006 DA - 2006// TI - The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome JO - Nat Genet VL - 38 UR - https://doi.org/10.1038/ng1830 DO - 10.1038/ng1830 ID - Sebaihia2006 ER - TY - JOUR AU - Forgetta, V. AU - Oughton, M. T. AU - Marquis, P. AU - Brukner, I. AU - Blanchette, R. AU - Haub, K. PY - 2011 DA - 2011// TI - Fourteen-Genome Comparison Identifies DNA Markers for Severe-Disease-Associated Strains of Clostridium difficile JO - J Clin Microbiol VL - 49 UR - https://doi.org/10.1128/JCM.00391-11 DO - 10.1128/JCM.00391-11 ID - Forgetta2011 ER - TY - JOUR AU - Marsden, G. L. AU - Davis, I. J. AU - Wright, V. J. AU - Sebaihia, M. AU - Kuijper, E. J. AU - Minton, N. P. PY - 2010 DA - 2010// TI - Array comparative hybridisation reveals a high degree of similarity between UK and European clinical isolates of hypervirulent Clostridium difficile JO - BMC Genomics VL - 11 UR - https://doi.org/10.1186/1471-2164-11-389 DO - 10.1186/1471-2164-11-389 ID - Marsden2010 ER - TY - JOUR AU - Stabler, R. A. AU - Gerding, D. N. AU - Songer, J. G. AU - Drudy, D. AU - Brazier, J. S. AU - Trinh, H. T. PY - 2006 DA - 2006// TI - Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains JO - J Bacteriol VL - 188 UR - https://doi.org/10.1128/JB.00664-06 DO - 10.1128/JB.00664-06 ID - Stabler2006 ER - TY - JOUR AU - Brouwer, M. S. M. AU - Warburton, P. J. AU - Roberts, A. P. AU - Mullany, P. AU - Allan, E. PY - 2011 DA - 2011// TI - Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0023014 DO - 10.1371/journal.pone.0023014 ID - Brouwer2011 ER - TY - JOUR AU - Tan, K. S. AU - Wee, B. Y. AU - Song, K. P. PY - 2001 DA - 2001// TI - Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile JO - J Med Microbiol VL - 50 UR - https://doi.org/10.1099/0022-1317-50-7-613 DO - 10.1099/0022-1317-50-7-613 ID - Tan2001 ER - TY - JOUR AU - Braun, V. AU - Hundsberger, T. AU - Leukel, P. AU - Sauerborn, M. AU - von Eichel-Streiber, C. PY - 1996 DA - 1996// TI - Definition of the single integration site of the pathogenicity locus in Clostridium difficile JO - Gene VL - 181 UR - https://doi.org/10.1016/S0378-1119(96)00398-8 DO - 10.1016/S0378-1119(96)00398-8 ID - Braun1996 ER - TY - JOUR AU - Govind, R. AU - Vediyappan, G. AU - Rolfe, R. D. AU - Dupuy, B. AU - Fralick, J. A. PY - 2009 DA - 2009// TI - Bacteriophage-mediated toxin gene regulation in Clostridium difficile JO - J Virol VL - 83 UR - https://doi.org/10.1128/JVI.01256-09 DO - 10.1128/JVI.01256-09 ID - Govind2009 ER - TY - JOUR AU - Sekulovic, O. AU - Meessen-Pinard, M. AU - Fortier, L. C. PY - 2011 DA - 2011// TI - Prophage-Stimulated Toxin Production in Clostridium difficile NAP1/027 Lysogens JO - J Bacteriol VL - 193 UR - https://doi.org/10.1128/JB.00787-10 DO - 10.1128/JB.00787-10 ID - Sekulovic2011 ER - TY - JOUR AU - Bakker, D. AU - Corver, J. AU - Harmanus, C. AU - Goorhuis, A. AU - Keessen, E. C. AU - Fawley, W. N. PY - 2010 DA - 2010// TI - Relatedness of human and animal Clostridium difficile PCR ribotype 078 isolates determined on the basis of multilocus variable-number tandem-repeat analysis and tetracycline resistance JO - J Clin Microbiol VL - 48 UR - https://doi.org/10.1128/JCM.01171-10 DO - 10.1128/JCM.01171-10 ID - Bakker2010 ER - TY - JOUR AU - Adams, V. AU - Lyras, D. AU - Farrow, K. A. AU - Rood, J. I. PY - 2002 DA - 2002// TI - The clostridial mobilisable transposons JO - Cell Mol Life Sci VL - 59 UR - https://doi.org/10.1007/s000180200003 DO - 10.1007/s000180200003 ID - Adams2002 ER - TY - JOUR AU - Roberts, A. P. AU - Mullany, P. PY - 2009 DA - 2009// TI - A modular master on the move: the Tn916 family of mobile genetic elements JO - Trends Microbiol VL - 17 UR - https://doi.org/10.1016/j.tim.2009.03.002 DO - 10.1016/j.tim.2009.03.002 ID - Roberts2009 ER - TY - CHAP AU - Brouwer, M. S. M. AU - Roberts, A. P. AU - Mullany, P. AU - Allan, E. PY - 2012 DA - 2012// TI - In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes BT - Mobile Genetic Elements ID - Brouwer2012 ER - TY - JOUR AU - Mullany, P. AU - Wilks, M. AU - Lamb, I. AU - Clayton, C. AU - Wren, B. AU - Tabaqchali, S. PY - 1990 DA - 1990// TI - Genetic analysis of a tetracycline resistance element from Clostridium difficile and its conjugal transfer to and from Bacillus subtilis JO - J Gen Microbiol VL - 136 UR - https://doi.org/10.1099/00221287-136-7-1343 DO - 10.1099/00221287-136-7-1343 ID - Mullany1990 ER - TY - JOUR AU - Wang, H. AU - Roberts, A. P. AU - Lyras, D. AU - Rood, J. I. AU - Wilks, M. AU - Mullany, P. PY - 2000 DA - 2000// TI - Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX JO - J Bacteriol VL - 182 UR - https://doi.org/10.1128/JB.182.13.3775-3783.2000 DO - 10.1128/JB.182.13.3775-3783.2000 ID - Wang2000 ER - TY - JOUR AU - Camilli, R. AU - Del, G. M. AU - Iannelli, F. AU - Pantosti, A. PY - 2008 DA - 2008// TI - New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae JO - Antimicrob Agents Chemother VL - 52 UR - https://doi.org/10.1128/AAC.01081-07 DO - 10.1128/AAC.01081-07 ID - Camilli2008 ER - TY - JOUR AU - Kobayashi, I. PY - 2001 DA - 2001// TI - Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolution JO - Nucleic Acids Res VL - 29 UR - https://doi.org/10.1093/nar/29.18.3742 DO - 10.1093/nar/29.18.3742 ID - Kobayashi2001 ER - TY - JOUR AU - Murphy, E. PY - 1985 DA - 1985// TI - Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9) JO - Mol Gen Genet VL - 200 UR - https://doi.org/10.1007/BF00383309 DO - 10.1007/BF00383309 ID - Murphy1985 ER - TY - JOUR AU - Chen, C. AU - Tang, J. AU - Dong, W. AU - Wang, C. AU - Feng, Y. AU - Wang, J. PY - 2007 DA - 2007// TI - A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates JO - PLoS One VL - 2 UR - https://doi.org/10.1371/journal.pone.0000315 DO - 10.1371/journal.pone.0000315 ID - Chen2007 ER - TY - JOUR AU - Abril, C. AU - Brodard, I. AU - Perreten, V. PY - 2010 DA - 2010// TI - Two novel antibiotic resistance genes, tet(44) and ant(6)-Ib, are located within a transferable pathogenicity island in Campylobacter fetus subsp. fetus JO - Antimicrob Agents Chemother VL - 54 UR - https://doi.org/10.1128/AAC.00304-10 DO - 10.1128/AAC.00304-10 ID - Abril2010 ER - TY - JOUR AU - Smith, M. C. AU - Thorpe, H. M. PY - 2002 DA - 2002// TI - Diversity in the serine recombinases JO - Mol Microbiol VL - 44 UR - https://doi.org/10.1046/j.1365-2958.2002.02891.x DO - 10.1046/j.1365-2958.2002.02891.x ID - Smith2002 ER - TY - JOUR AU - Roberts, A. P. AU - Chandler, M. AU - Courvalin, P. AU - Guedon, G. AU - Mullany, P. AU - Pembroke, T. PY - 2008 DA - 2008// TI - Revised nomenclature for transposable genetic elements JO - Plasmid VL - 60 UR - https://doi.org/10.1016/j.plasmid.2008.08.001 DO - 10.1016/j.plasmid.2008.08.001 ID - Roberts2008 ER - TY - JOUR AU - Su, Y. A. AU - He, P. AU - Clewell, D. B. PY - 1992 DA - 1992// TI - Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation JO - Antimicrob Agents Chemother VL - 36 UR - https://doi.org/10.1128/AAC.36.4.769 DO - 10.1128/AAC.36.4.769 ID - Su1992 ER - TY - JOUR AU - Ciric, L. AU - Mullany, P. AU - Roberts, A. P. PY - 2011 DA - 2011// TI - Antibiotic and antiseptic resistance genes are linked on a novel mobile genetic element: Tn6087 JO - J Antimicrob Chemother VL - 66 UR - https://doi.org/10.1093/jac/dkr311 DO - 10.1093/jac/dkr311 ID - Ciric2011 ER - TY - JOUR AU - Knetsch, C. W. AU - Hensgens, M. P. M. AU - Harmanus, C. AU - van der Bijl, M. W. AU - Savelkoul, P. H. AU - Kuijper, E. J. PY - 2011 DA - 2011// TI - Genetic markers for Clostridium difficile lineages linked to hypervirulence JO - Microbiology VL - 157 UR - https://doi.org/10.1099/mic.0.051953-0 DO - 10.1099/mic.0.051953-0 ID - Knetsch2011 ER - TY - JOUR AU - Bauer, M. P. AU - Notermans, D. W. AU - van Benthem, B. H. AU - Brazier, J. S. AU - Wilcox, M. H. AU - Rupnik, M. PY - 2011 DA - 2011// TI - Clostridium difficile infection in Europe: a hospital-based survey JO - Lancet VL - 377 UR - https://doi.org/10.1016/S0140-6736(10)61266-4 DO - 10.1016/S0140-6736(10)61266-4 ID - Bauer2011 ER - TY - JOUR AU - Griffiths, D. AU - Fawley, W. AU - Kachrimanidou, M. AU - Bowden, R. AU - Crook, D. W. AU - Fung, R. PY - 2010 DA - 2010// TI - Multilocus sequence typing of Clostridium difficile JO - J Clin Microbiol VL - 48 UR - https://doi.org/10.1128/JCM.01796-09 DO - 10.1128/JCM.01796-09 ID - Griffiths2010 ER - TY - JOUR AU - Stabler, R. A. AU - Dawson, L. F. AU - Valiente, E. AU - Cairns, M. D. AU - Martin, M. J. AU - Donahue, E. H. PY - 2012 DA - 2012// TI - Macro and Micro Diversity of Clostridium difficile Isolates from Diverse Sources and Geographical Locations JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0031559 DO - 10.1371/journal.pone.0031559 ID - Stabler2012 ER - TY - JOUR AU - Dingle, K. E. AU - Griffiths, D. AU - Didelot, X. AU - Evans, J. AU - Vaughan, A. AU - Kachrimanidou, M. PY - 2011 DA - 2011// TI - Clinical Clostridium difficile: clonality and pathogenicity locus diversity JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0019993 DO - 10.1371/journal.pone.0019993 ID - Dingle2011 ER - TY - JOUR AU - Fawley, W. N. AU - Freeman, J. AU - Smith, C. AU - Harmanus, C. AU - van den Berg, R. J. AU - Kuijper, E. J. PY - 2008 DA - 2008// TI - Use of highly discriminatory fingerprinting to analyze clusters of Clostridium difficile infection cases due to epidemic Type 027 strains JO - J Clin Microbiol VL - 46 UR - https://doi.org/10.1128/JCM.01764-07 DO - 10.1128/JCM.01764-07 ID - Fawley2008 ER - TY - JOUR AU - van den Berg, R. J. AU - Schaap, I. AU - Templeton, K. E. AU - Klaassen, C. H. AU - Kuijper, E. J. PY - 2007 DA - 2007// TI - Typing and subtyping of Clostridium difficile isolates by using multiple-locus variable-number tandem-repeat analysis JO - J Clin Microbiol VL - 45 UR - https://doi.org/10.1128/JCM.02023-06 DO - 10.1128/JCM.02023-06 ID - van den Berg2007 ER - TY - JOUR AU - Goorhuis, A. AU - Legaria, M. C. AU - van den Berg, R. J. AU - Harmanus, C. AU - Klaassen, C. H. AU - Brazier, J. S. PY - 2009 DA - 2009// TI - Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina JO - Clin Microbiol Infect VL - 15 UR - https://doi.org/10.1111/j.1469-0691.2009.02759.x DO - 10.1111/j.1469-0691.2009.02759.x ID - Goorhuis2009 ER - TY - JOUR AU - Paltansing, S. AU - van den Berg, R. J. AU - Guseinova, R. A. AU - Visser, C. E. AU - van der Vorm, E. R. AU - Kuijper, E. J. PY - 2007 DA - 2007// TI - Characteristics and incidence of Clostridium difficile-associated disease, The Netherlands, 2005 JO - Clin Microbiol Infect VL - 13 UR - https://doi.org/10.1111/j.1469-0691.2007.01793.x DO - 10.1111/j.1469-0691.2007.01793.x ID - Paltansing2007 ER - TY - JOUR AU - Bidet, P. AU - Barbut, F. AU - Lalande, V. AU - Burghoffer, B. AU - Petit, J. C. PY - 1999 DA - 1999// TI - Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencing JO - FEMS Microbiol Lett VL - 175 UR - https://doi.org/10.1111/j.1574-6968.1999.tb13629.x DO - 10.1111/j.1574-6968.1999.tb13629.x ID - Bidet1999 ER - TY - JOUR AU - Hachler, H. AU - Kayser, F. H. AU - Berger-Bachi, B. PY - 1987 DA - 1987// TI - Homology of a transferable tetracycline resistance determinant of Clostridium difficile with Streptococcus (Enterococcus) faecalis transposon Tn916 JO - Antimicrob Agents Chemother VL - 31 UR - https://doi.org/10.1128/AAC.31.7.1033 DO - 10.1128/AAC.31.7.1033 ID - Hachler1987 ER - TY - JOUR AU - Brouwer, M. S. AU - Allan, E. AU - Mullany, P. AU - Roberts, A. P. PY - 2012 DA - 2012// TI - Draft Genome Sequence of the Nontoxigenic Clostridium difficile Strain CD37 JO - J Bacteriol VL - 194 UR - https://doi.org/10.1128/JB.00122-12 DO - 10.1128/JB.00122-12 ID - Brouwer2012 ER - TY - JOUR AU - van den Berg, R. J. AU - Claas, E. C. AU - Oyib, D. H. AU - Klaassen, C. H. AU - Dijkshoorn, L. AU - Brazier, J. S. PY - 2004 DA - 2004// TI - Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping JO - J Clin Microbiol VL - 42 UR - https://doi.org/10.1128/JCM.42.3.1035-1041.2004 DO - 10.1128/JCM.42.3.1035-1041.2004 ID - van den Berg2004 ER - TY - JOUR AU - Carver, T. AU - Berriman, M. AU - Tivey, A. AU - Patel, C. AU - Bohme, U. AU - Barrell, B. G. PY - 2008 DA - 2008// TI - Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database JO - Bioinformatics VL - 24 UR - https://doi.org/10.1093/bioinformatics/btn529 DO - 10.1093/bioinformatics/btn529 ID - Carver2008 ER - TY - JOUR AU - Hussain, H. A. AU - Roberts, A. P. AU - Mullany, P. PY - 2005 DA - 2005// TI - Generation of an erythromycin-sensitive derivative of Clostridium difficile strain 630 (630Deltaerm) and demonstration that the conjugative transposon Tn916DeltaE enters the genome of this strain at multiple sites JO - J Med Microbiol VL - 54 UR - https://doi.org/10.1099/jmm.0.45790-0 DO - 10.1099/jmm.0.45790-0 ID - Hussain2005 ER - TY - JOUR AU - Carver, T. AU - Thomson, N. AU - Bleasby, A. AU - Berriman, M. AU - Parkhill, J. PY - 2009 DA - 2009// TI - DNAPlotter: circular and linear interactive genome visualization JO - Bioinformatics VL - 25 UR - https://doi.org/10.1093/bioinformatics/btn578 DO - 10.1093/bioinformatics/btn578 ID - Carver2009 ER -