From: Metagenome analyses of corroded concrete wastewater pipe biofilms reveal a complex microbial system
Subsystem | Gene | n | % of genomes with gene†| q-value* | Odds ratio | ||
---|---|---|---|---|---|---|---|
TP | BP | TP/BP | BP/TP | ||||
Single-copy genes ‡ |  | 5 | 100 | 100 | ns | 1.0 | 1.0 |
Heavy metal resistance | Â | Â | Â | Â | Â | Â | Â |
Arsenate reductase (glutaredoxin) | arsC | 1 | 50 | 17 | 0.000 | 2.8 | 0.4 |
Arsenic efflux pump protein | arsB | 1 | 24 | 10 | 0.000 | 2.4 | 0.4 |
Arsenic resistance protein | arsH | 1 | 37 | 5 | 0.000 | 7.4 | 0.1 |
Arsenical pump-driving (ATPase) | arsA | 1 | 15 | 28 | 0.000 | 0.5 | 1.9 |
Arsenite oxidase | aoxB | 1 | 10 | 8 | ns | 1.3 | 0.8 |
Cadmium-transporting (ATPase) | cadA | 1 | 3 | 14 | 0.000 | 0.2 | 4.5 |
Chromate transport protein | chrA | 1 | 40 | 50 | 0.034 | 0.8 | 1.3 |
Copper-translocating P-type (ATPase) | copA | 1 | >100 | >100 | ns | 1.1 | 0.9 |
CZC resistance protein | czcD | 1 | >100 | 75 | 0.006 | 1.6 | 0.6 |
Mercuric reductase | merA | 1 | 80 | 33 | 0.000 | 2.4 | 0.4 |
Antibiotics & toxicity resistance | Â | Â | Â | Â | Â | Â | Â |
Beta-lactamase | ampC | 1 | >100 | >100 | 0.000 | 1.8 | 0.6 |
Beta-lactamase (MRSA) | mecA | 1 | 0 | 0 | nd | 0 | 0 |
Dihydrofolate reductase | folA | 1 | 80 | 47 | 0.034 | 1.6 | 0.6 |
Pterin binding enzyme | sul | 1 | 83 | 66 | 0.003 | 1.3 | 0.8 |
Multidrug efflux system protein | acrB | 1 | >100 | >100 | 0.000 | 1.4 | 0.7 |
Dioxygenase (Bleomycin resistance) | bleO | 1 | >100 | >100 | 0.000 | 2.3 | 0.4 |
Aminoglycoside-3’-adenylyltransferase | aadA | 1 | 40 | >100 | 0.000 | 0.3 | 3.2 |
Antiholin-like protein (murein hydrolase) | lrgA | 1 | 4 | 37 | 0.000 | 0.1 | 9.6 |
Antiholin-like protein (murein hydrolase) | lrgB | 1 | 17 | 39 | 0.001 | 0.4 | 2.5 |
Streptomycin adenylyltransferase | ant1 | 1 | 0 | 3 | 0.031 | 0.0 | nd |
Drug resistance transporter | cflA | 1 | 61 | 37 | 0.000 | 1.6 | 0.6 |
MFS transporter (DHA2) | emrB | 1 | >100 | 57 | 0.000 | 3.6 | 0.3 |
D-alanine--D-alanine ligase | vanA | 1 | 76 | 81 | ns | 0.9 | 1.1 |
Multi antimicrobial extrusion protein | norM | 1 | 6 | 40 | 0.000 | 0.2 | 6.6 |
Multidrug efflux transporter | mexF | 1 | 16 | 6 | 0.043 | 2.7 | 0.4 |
RND efflux system (transporter) | cmeB | 1 | 53 | >100 | 0.000 | 0.5 | 2.1 |
RND efflux system (membrane protein) | cmeA | 1 | 18 | 46 | 0.005 | 0.4 | 2.5 |
RND efflux system (lipoprotein) | cmeC | 1 | 19 | 60 | 0.020 | 0.3 | 3.1 |
Protein secretion systems | Â | Â | Â | Â | Â | Â | Â |
Type I | -- | 1 | nd | nd | 0.000 | 1.5 | 0.7 |
Type III | -- | 10 | nd | nd | 0.001 | 0.8 | 1.8 |
Type IV | -- | 5 | nd | nd | 0.000 | 3.1 | 1.4 |
Type V | -- | 3 | nd | nd | 0.001 | 1.7 | 0.6 |
Type VI | -- | 10 | nd | nd | 0.000 | 2.8 | 0.7 |
Motility & Chemotaxis systems | Â | Â | Â | Â | Â | Â | Â |
motility/chemotaxis | -- | 74 | nd | nd | 0.000 | 0.7 | 2.7 |
Stress systems | Â | Â | Â | Â | Â | Â | Â |
stress response | -- | 276 | nd | nd | 0.000 | 2.2 | 1.8 |