Figure 2
From: Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis
MMP-9−/−and WT mice infected with C. rodentium have similar histopathology and mucosal barrier dysfunction. (A) Representative H & E stained images of colonic tissues demonstrating C. rodentium-induced inflammation in MMP-9+/+ and MMP-9−/− mice. Scale bar, 100 μm. (B) Quantitative analysis shows significant increases in colonic crypt height in MMP-9+/+ and MMP-9−/− mice at 10d and 30d PI, compared to sham-infected mice. N = 12-18. (C) Fluorometric analysis of a 4 kDa FITC-dextran probe in serum samples obtained from WT and MMP-9−/− mice in the presence or absence of C. rodentium infection (10d and 30d PI). *P<0.05 compared to Sham WT; #P<0.05 compared to Sham MMP-9−/−. N = 7-17.