Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A

Table 2 Gene Ontology (GO) term analysis for the C. neoformans FLC response

GO group	GO subgroup	P-value
Up-regulated genes
Oxidation reduction		5.26e^-10
Small molecule metabolic process		1.34e^-06
	Alcohol metabolic process	4.74e^-07
	Sterol metabolic process	4.41e^-07
Steroid metabolic process		7.81e^-07
	Phytosteroid metabolic process	1.47e^-09
	Steroid biosynthetic process	9.08e^-07
	Ergosterol biosynthetic process	3.57e^-08
Transmembrane transport		0.00076
Down-regulated genes
Oxidation reduction		1.31e^-12
Small molecule metabolic process		2.50e^-11
	Alcohol metabolic process	0.00037
	Cellular ketone metabolic process	1.25e^-08
	Cellular amino acid and derivative metabolic process	3.74e^-12
	Organic acid metabolic process	1.63e^-08
Amine metabolic process		1.47e^-13
	Gamma-aminobutyric acid metabolic process	0.00078

GO term assignment for C. neoformans H99 genes was based on homology to S. cerevisiae genes. P-value represents the probability that a particular GO term is enriched in the microarray gene list. The P-value cut-off was < 0.05.

ISSN: 1471-2180