Table 1 Changes in the gene expression of C. neoformans H99 cells exposed to FLC

04804

SRE1

Sterol regulatory element-binding protein 1

+ 4.04

01737

ERG25

C-4 methyl sterol oxidase

+ 3.95

00854

ERG2

C-8 sterol isomerase

+ 3.47

02896

ERG13

Hydroxymethylglutaryl-CoA synthase

+ 3.03

06644

ERG5

C-22 sterol desaturase

+ 2.50

00040

ERG11

ERG11

Lanosterol 14 alpha-demethylase

+ 2.47

06829

ERG1

Squalene monooxygenase

+ 2.37

00519

ERG3

C-5 sterol desaturase

+ 2.21

01129

ERG7

Lanosterol synthase

+ 2.09

04632

FUR4

Uracil permease

+ 5.87

07448

DUR3

Urea transporter

+ 4.78

04758

MEP2/AMP2

Ammonium transporter

+ 3.78

06652

DAL5

Allantoate permease

+ 2.83

01742

AQY1

Water channel

+ 2.73

07902

CAN1

Amino acid transporter

+ 2.52

01960

YMR279C

Efflux protein EncT

+ 2.47

06338

PDR15

ABC transporter PMR5

+ 2.37

04898

ATR1

MFS transporter

+ 2.37

00284

YOR378W

Efflux protein EncT

+ 2.36

00097

ITR1

ITR1

+ 2.26

00895

ZRT1

Low-affinity zinc ion transporter

+ 2.20

04210

MPH2

Sugar transporter

+ 2.15

04617

OPT2

Small oligopeptide transporter

+ 2.11

05592

PMR1

Calcium-transporting ATPase

+ 2.06

01059

YBR241C

Vacuolar membrane protein

+ 2.02

00904

AZR1

Aflatoxin efflux pump AFLT

- 2.10

01769

AGC1

Mitochondrial inner membrane protein

- 2.16

04142

FEN2

Tartrate transporter

- 2.17

04567

TPO2

Drug transporter

- 2.22

05387

HXT5

Galactose transporter

- 2.28

02355

YEA4

UDP-N-acetylglucosamine transporter

- 2.30

05994

FLR1

Multidrug transporter

- 2.35

02733

STL1

Hexose transport-related protein

- 2.46

03794

YBR287W

Endoplasmic reticulum protein

- 2.58

00815

SIT1

Siderochrome-iron (Ferrioxamine) uptake transporter

- 2.92

01354

TNA1

Transporter

- 3.39

02104

SFH5

SFH5

Phosphatidylinositol transfer protein SFH5

- 4.54

07695

UGA4

Gamma-aminobutyric acid transporter

- 5.16

00749

YIL166C

Transporter

- 5.65

02083

ARN2

Siderochrome-iron transporter

- 9.48

02217

CHS7

Chitin synthase 7

+ 3.62

06336

BGL2

Glucan 1,3 beta-glucosidase protein

+ 2.61

03326

CHS2

Chitin synthase 2, CHS2

+ 2.20

01239

CDA3

CDA2

Chitin deacetylase

- 4.35

03644

CAS3

CAS3p

+ 12.16

01489

CAS9

YJL218W

Putative O-acetyl transferase

- 3.84

06085

PLB1

PLB1

Phospholipase B

+ 2.18

06623

MIOX

Myo-inositol oxygenase

+ 2.12

03128

ECM38

Lincomycin-condensing protein lmbA

- 2.01

00424

PCT1

Choline-phosphate cytidylyltransferase

- 2.02

05042

CAT2

Carnitine acetyltransferase

- 2.10

02000

FOX2

Short-chain dehydrogenase

- 2.95

00834

PSD2

Phosphatidylserine decarboxylase

- 3.10

02968

PLC2

Phospholipase C-2

- 4.11

03400

GRE2

Oxidoreductase

+ 3.54

05256

CTA1

Catalase 2

+ 2.81

02440

HSC82

Cation-transporting ATPase

+ 2.54

01750

HSP70

SSA1

Heat shock protein 70

+ 2.48

06917

TSA3

PRX1

Thiol-specific antioxidant protein 3

+ 2.09

03185

LOT6

Low temperature-responsive protein

+ 2.05

04622

SNG1

Response to drug-related protein

- 2.17

00575

CTT1

Catalase

- 2.21

01464

FHB1

YHB1

Flavo-haemoglobin

- 2.32

02284

PDA1

Branched-chain alpha-keto acid dehydrogenase E1-alpha subunit

+ 2.42

04862

GLT1

Glutamate synthase (NADH)

+ 2.39

04017

MXR2

Protein-methionine-R-oxide reductase

+ 2.32

01231

CAR1

Arginase

+ 2.27

03828

ARO8

Aromatic amino acid aminotransferase I

+ 2.26

06540

ILV3

Dihydroxy-acid dehydratase

+ 2.18

00247

LYS9

Saccharopine dehydrogenase (NADP+, L-glutamate-forming)

+ 2.02

02270

MET2

Homoserine O-acetyltransferase

- 2.11

01076

UGA1

4-aminobutyrate transaminase

- 2.18

00237

LEU1

3-isopropylmalate dehydratase

- 2.27

01264

LYS12

Isocitrate dehydrogenase

- 2.31

00879

GDH2

Glutamate dehydrogenase

- 2.33

04467

UGA2

Succinate-semialdehyde dehydrogenase (NAD(P)+)

- 2.83

02851

GLY1

Threonine aldolase

- 3.04

02049

PUT1

Proline dehydrogenase

- 5.74

05602

PUT2

1-pyrroline-5-carboxylate dehydrogenase

- 6.65

06374

MAE1

Malic enzyme

+ 6.04

02225

CELC

EXG1

Cellulase

+ 3.99

02552

TKL1

Transketolase

+ 3.28

04025

TAL1

Transaldolase

+ 3.00

00696

AMS1

Alpha-mannosidase

+ 2.52

05913

MAL12

Alpha-glucosidase

+ 2.34

05113

ALD4

Aldehyde dehydrogenase (ALDDH)

+ 2.11

05264

YJL216C

Alpha-amylase AmyA

+ 2.08

03946

GAL1

Galactokinase

- 2.16

07752

GLF

UDP-galactopyranose mutase

- 2.23

04659

PDC1

Pyruvate decarboxylase

- 2.33

06924

SUC2

Beta-fructofuranosidase

- 2.57

00269

SOR1

Sorbitol dehydrogenase

- 2.62

00393

GLC3

GLC3

1,4-alpha-glucan-branching enzyme

- 2.93

07745

MPD1

ADH3

Mannitol-1-phosphate dehydrogenase

- 3.54

04217

PCK1

Phosphoenolpyruvate carboxykinase

- 8.67

04621

GSY1

Glycogen (Starch) synthase

- 11.00

04523

TDH3

Glyceraldehyde-3-phosphate dehydrogenase

- 11.45

02389

YPK1

AGC-group protein kinase

+ 3.04

02531

FUS3

Mitogen-activated protein kinase CPK1

+ 2.91

03176

ERO1

Endoplasmic oxidoreductin 1

+ 2.36

05932

CPR6

CPR6

Peptidyl-prolyl cis-trans isomerase D

+ 2.35

01861

NAS6

Proteolysis and peptidolysis-related protein

+ 2.35

04635

PEP4

Endopeptidase

+ 2.31

06872

YKL215C

5-oxoprolinase

+ 2.27

05005

ATG1

ATG1

Serine/threonine-protein kinase ATG1

+ 2.20

00919

KEX1

Carboxypeptidase D

+ 2.13

04625

PRB1

Serine-type endopeptidase

- 2.01

00130

RCK2

Serine/threonine-protein kinase

- 2.12

04108

PKP1

Kinase

- 2.17

02327

YFR006W

Prolidase

- 2.28

02418

DED81

Asparagine-tRNA ligase

- 2.40

03563

DPS1

Aspartate-tRNA ligase

- 2.50

04275

OMA1

Metalloendopeptidase

- 2.50

02006

NTA1

Protein N-terminal asparagine amidohydrolase

- 2.75

03949

PHO13

4-nitrophenylphosphatase

- 3.32

03596

KGD2

2-oxoglutarate metabolism-related protein

- 2.02

03920

IDP1

Isocitrate dehydrogenase (NADP+)

- 2.06

03674

KGD1

Oxoglutarate dehydrogenase (Succinyl-transferring)

- 2.52

00747

LSC2

Succinate-CoA ligase (ADP-forming)

- 2.70

07363

IDH2

Isocitrate dehydrogenase

- 2.80

01137

ACO1

Aconitase

- 2.99

07851

IDH1

Isocitrate dehydrogenase (NAD+), putative

- 3.80

06132

RHR2

Glycerol-1-phosphatase

+ 2.31

02815

GUT2

Glycerol-3-phosphate dehydrogenase

- 2.00

05545

HNT2

Nucleoside-triphosphatase

+ 2.25

03078

NPP1

Type I phosphodiesterase/nucleotide pyrophosphatase family protein

+ 2.08

06489

ADO1

Adenosine kinase

- 2.08

00613

FCY1

Cytosine deaminase

- 2.69

03592

THI20

Phosphomethylpyrimidine kinase

- 2.51

05258

SMG1

Glucose-methanol-choline (GMC) oxidoreductase

+ 6.67

05024

SPS19

L-xylulose reductase

+ 2.53

06168

GNO1

SFA1

GSNO reductase

- 2.02

05144

CAN2

NCE103

Carbonic anhydrase 2

- 3.18

03385

PCL1

G1/s-specific cyclin pcl1 (Cyclin hcs26)

+ 2.37

02604

HOP1

Putative uncharacterized protein

+ 2.19

00995

MSC1

Meiotic recombination-related protein

- 3.63

02115

NHP6B

Nonhistone protein 6

- 2.47

01841

GLN3

Predicted protein

+ 5.72

02990

YOR052C

Nucleus protein

+ 2.16

04594

UGA3

PRO1 protein

- 2.01

05290

SPT3

Transcription cofactor

- 2.01

06495

RNH70

Ribonuclease H

- 2.06

05333

PUT3

Putative uncharacterized protein

- 2.14

02338

GIS2

DNA-binding protein hexbp

- 2.47

05479

ASG1

Putative uncharacterized protein

- 3.57

03316

RDI1

Rho GDP-dissociation inhibitor 1

+ 2.07

00363

HHK5

SLN1

CnHHK5 protein

- 2.44

01262

GPB1

STE4

G-protein beta subunit GPB1

- 2.55

04652

YLR460C

Enoyl reductase

+ 2.63

06035

ADH1

Alcohol dehydrogenase

+ 2.41

00605

ZTA1

Cytoplasm protein

+ 2.20

00038

SOR2

Alcohol dehydrogenase

+ 2.13

01954

YPR127W

Aldo/keto reductase

+ 2.09

02958

FET5

Ferroxidase

+ 2.06

02935

YMR226C

Oxidoreductase

- 2.01

01558

XYL2

Zinc-binding dehydrogenase

- 2.28

00876

FRE7

Ferric-chelate reductase

- 2.49

03168

MET10

Sulfite reductase (NADPH)

- 2.55

07862

YEL047C

Fumarate reductase (NADH)

- 2.58

03498

FRE2

Metalloreductase

- 2.85

03874

AIF1

Oxidoreductase

- 2.89

00331

YMR210W

Anon-23da protein

+ 3.43

04934

TAR1

Temperature associated repressor

+ 2.37

05678

ADY2

Membrane protein

+ 2.28

00818

AGE2

AGD15

+ 2.23

04867

YJR054W

Vacuole protein

+ 2.22

06574

APP1

Antiphagocytic protein 1

+ 2.21

06482

AMD2

Amidase

+ 2.20

01252

TUM1

Thiosulfate sulfurtransferase

- 2.05

03452

AFG1

AFG1 family mitochondrial ATPase

- 2.16

05831

MMF1

Brt1

- 2.19

03991

YGR149W

Integral to membrane protein

- 2.39

02039

YPL264C

Integral membrane protein

- 2.46

02943

SLM1

Cytoplasm protein

- 2.49

06668

AIM38

Mitochondrion protein

- 2.61

00638

LSG1

GTPase

- 2.89

01653

CIG

Cytokine inducing-glycoprotein

- 3.26

04314

YEF1

NAD+ kinase

- 3.74

04690

FMP41

Mitochondrion protein

- 5.52