Skip to main content

Table 1 dosR regulon gene expression from transcriptional profiles of ssd merodiploid strain and the ssd::Tn mutant strain

From: Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response

Locus

Gene

Product

merodiploid

 

mutant

 

Δ

   

Log 2 exp

p-value

Log 2 exp

p-value

 

Rv0079

 

hypothetical protein

1.31

0.007

0.27

0.000

4.9

Rv0080

 

hypothetical protein

1.35

0.002

0.20

0.001

6.7

Rv0081

 

transcriptional regulator (ArsR family)

1.10

0.000

0.20

0.016

5.4

Rv0082

 

probable oxidoreductase subunit

0.46

0.011

0.28

0.063

1.7

Rv0083

 

probable oxidoreductase subunit

0.10

0.001

0.88

0.008

0.1

Rv0569

 

conserved hypothetical protein

1.26

0.000

0.29

0.003

4.3

Rv0570

nrdZ

ribonucleotide reductase, class II

1.19

0.018

-0.08

0.003

-15.0

Rv0571c

 

conserved hypothetical protein

0.14

0.025

-0.15

0.000

-0.9

Rv0572c

 

hypothetical protein

0.30

0.002

-0.41

0.013

-0.7

Rv0573c

 

conserved hypothetical protein

0.83

0.006

0.19

0.000

4.4

Rv0574c

 

conserved hypothetical protein

0.76

0.009

-0.23

0.006

-3.2

Rv1733c

 

possible membrane protein

1.99

0.068

0.33

0.002

6.0

Rv1734c

 

hypothetical protein

0.71

0.013

-0.04

0.009

-18.0

Rv1735c

 

hypothetical protein

0.50

0.001

0.14

0.012

3.4

Rv1736c

narX

fused nitrate reductase

1.09

0.032

0.07

0.000

15.0

Rv1737c

narK2

nitrite extrusion protein

1.87

0.228

0.20

0.001

9.2

Rv1738

 

conserved hypothetical protein

2.90

0.230

0.96

0.016

3.0

Rv1812c

 

probable dehydrogenase

0.03

0.324

-0.15

0.001

-0.2

Rv1813c

 

conserved hypothetical protein

1.26

0.257

1.83

0.030

0.7

Rv1996

 

conserved hypothetical protein

2.63

0.046

0.80

0.025

3.3

Rv1997

ctpF

probable cation transport ATPase

1.62

0.001

0.17

0.018

9.4

Rv1998c

 

conserved hypothetical protein

0.47

0.118

0.10

0.000

4.6

Rv2003c

 

conserved hypothetical protein

1.26

0.004

0.08

0.010

15.1

Rv2004c

 

hypothetical protein

1.01

0.008

0.36

0.022

2.8

Rv2005c

 

conserved hypothetical protein

1.78

0.033

0.33

0.000

5.4

Rv2006

otsB2

trehalose-6-phosphate phosphatase

1.28

0.000

0.02

0.008

78.4

Rv2007c

fdxA

ferredoxin

2.56

0.137

0.64

0.026

4.0

Rv2027c

dosT

sensor histidine kinase

1.35

0.001

0.07

0.044

18.9

Rv2028c

 

conserved hypothetical protein

0.38

0.009

-0.11

0.004

-3.3

Rv2029c

pfkB

phosphofructokinase II

2.03

0.330

0.26

0.006

7.8

Rv2030c

 

conserved hypothetical protein

3.37

0.195

0.62

0.004

5.4

Rv2031c

hspX

14 kD antigen, heat shock protein Hsp20 family

3.94

0.043

1.50

0.079

2.6

Rv2032

acg

conserved hypothetical protein

2.50

0.277

0.29

0.003

8.6

Rv2617c

 

hypothetical protein

-0.21

0.012

-0.01

0.000

20.6

Rv2623

 

conserved hypothetical protein

3.02

0.151

0.15

0.132

19.8

Rv2624c

 

conserved hypothetical protein

1.34

0.062

0.10

0.024

13.9

Rv2625c

 

conserved hypothetical protein

-0.03

0.016

-0.94

0.017

0.0

Rv2626c

 

conserved hypothetical protein

3.35

0.000

0.77

0.184

4.4

Rv2627c

 

conserved hypothetical protein

2.65

0.285

0.05

0.010

51.0

Rv2628

 

hypothetical protein

2.22

0.022

0.14

0.038

16.0

Rv2629

 

hypothetical protein

0.49

0.004

0.28

0.006

1.8

Rv2630

 

hypothetical protein

1.42

0.003

0.24

0.014

5.9

Rv2631

 

conserved hypothetical protein

0.70

0.015

-0.17

0.021

-4.1

Rv2830c

 

similar to phage P1 phd gene

0.29

0.000

-0.07

0.002

-3.9

Rv3126c

 

hypothetical protein

0.91

0.021

0.07

0.018

12.8

Rv3127

 

conserved hypothetical protein

2.15

0.044

0.51

0.000

4.2

Rv3128c

 

conserved hypothetical protein

0.30

0.310

0.13

0.002

2.3

Rv3129

 

conserved hypothetical protein

1.09

0.002

0.03

0.035

40.6

Rv3130c

tgs1

conserved hypothetical protein

3.92

0.309

0.84

0.013

4.7

Rv3131

 

conserved hypothetical protein

4.01

0.273

1.66

0.189

2.4

Rv3132c

dosS

sensor histidine kinase

2.00

0.014

0.18

0.001

11.0

Rv3133c

dosR

two-component response regulator

1.00

0.070

0.22

0.009

4.5

Rv3134c

 

conserved hypothetical protein

2.45

0.024

0.16

0.002

15.0

Rv3841

bfrB

bacterioferritin

1.22

0.106

1.36

0.087

0.9