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Table 1 dosR regulon gene expression from transcriptional profiles of ssd merodiploid strain and the ssd::Tn mutant strain

From: Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress response

Locus Gene Product merodiploid   mutant   Δ
    Log 2 exp p-value Log 2 exp p-value  
Rv0079   hypothetical protein 1.31 0.007 0.27 0.000 4.9
Rv0080   hypothetical protein 1.35 0.002 0.20 0.001 6.7
Rv0081   transcriptional regulator (ArsR family) 1.10 0.000 0.20 0.016 5.4
Rv0082   probable oxidoreductase subunit 0.46 0.011 0.28 0.063 1.7
Rv0083   probable oxidoreductase subunit 0.10 0.001 0.88 0.008 0.1
Rv0569   conserved hypothetical protein 1.26 0.000 0.29 0.003 4.3
Rv0570 nrdZ ribonucleotide reductase, class II 1.19 0.018 -0.08 0.003 -15.0
Rv0571c   conserved hypothetical protein 0.14 0.025 -0.15 0.000 -0.9
Rv0572c   hypothetical protein 0.30 0.002 -0.41 0.013 -0.7
Rv0573c   conserved hypothetical protein 0.83 0.006 0.19 0.000 4.4
Rv0574c   conserved hypothetical protein 0.76 0.009 -0.23 0.006 -3.2
Rv1733c   possible membrane protein 1.99 0.068 0.33 0.002 6.0
Rv1734c   hypothetical protein 0.71 0.013 -0.04 0.009 -18.0
Rv1735c   hypothetical protein 0.50 0.001 0.14 0.012 3.4
Rv1736c narX fused nitrate reductase 1.09 0.032 0.07 0.000 15.0
Rv1737c narK2 nitrite extrusion protein 1.87 0.228 0.20 0.001 9.2
Rv1738   conserved hypothetical protein 2.90 0.230 0.96 0.016 3.0
Rv1812c   probable dehydrogenase 0.03 0.324 -0.15 0.001 -0.2
Rv1813c   conserved hypothetical protein 1.26 0.257 1.83 0.030 0.7
Rv1996   conserved hypothetical protein 2.63 0.046 0.80 0.025 3.3
Rv1997 ctpF probable cation transport ATPase 1.62 0.001 0.17 0.018 9.4
Rv1998c   conserved hypothetical protein 0.47 0.118 0.10 0.000 4.6
Rv2003c   conserved hypothetical protein 1.26 0.004 0.08 0.010 15.1
Rv2004c   hypothetical protein 1.01 0.008 0.36 0.022 2.8
Rv2005c   conserved hypothetical protein 1.78 0.033 0.33 0.000 5.4
Rv2006 otsB2 trehalose-6-phosphate phosphatase 1.28 0.000 0.02 0.008 78.4
Rv2007c fdxA ferredoxin 2.56 0.137 0.64 0.026 4.0
Rv2027c dosT sensor histidine kinase 1.35 0.001 0.07 0.044 18.9
Rv2028c   conserved hypothetical protein 0.38 0.009 -0.11 0.004 -3.3
Rv2029c pfkB phosphofructokinase II 2.03 0.330 0.26 0.006 7.8
Rv2030c   conserved hypothetical protein 3.37 0.195 0.62 0.004 5.4
Rv2031c hspX 14 kD antigen, heat shock protein Hsp20 family 3.94 0.043 1.50 0.079 2.6
Rv2032 acg conserved hypothetical protein 2.50 0.277 0.29 0.003 8.6
Rv2617c   hypothetical protein -0.21 0.012 -0.01 0.000 20.6
Rv2623   conserved hypothetical protein 3.02 0.151 0.15 0.132 19.8
Rv2624c   conserved hypothetical protein 1.34 0.062 0.10 0.024 13.9
Rv2625c   conserved hypothetical protein -0.03 0.016 -0.94 0.017 0.0
Rv2626c   conserved hypothetical protein 3.35 0.000 0.77 0.184 4.4
Rv2627c   conserved hypothetical protein 2.65 0.285 0.05 0.010 51.0
Rv2628   hypothetical protein 2.22 0.022 0.14 0.038 16.0
Rv2629   hypothetical protein 0.49 0.004 0.28 0.006 1.8
Rv2630   hypothetical protein 1.42 0.003 0.24 0.014 5.9
Rv2631   conserved hypothetical protein 0.70 0.015 -0.17 0.021 -4.1
Rv2830c   similar to phage P1 phd gene 0.29 0.000 -0.07 0.002 -3.9
Rv3126c   hypothetical protein 0.91 0.021 0.07 0.018 12.8
Rv3127   conserved hypothetical protein 2.15 0.044 0.51 0.000 4.2
Rv3128c   conserved hypothetical protein 0.30 0.310 0.13 0.002 2.3
Rv3129   conserved hypothetical protein 1.09 0.002 0.03 0.035 40.6
Rv3130c tgs1 conserved hypothetical protein 3.92 0.309 0.84 0.013 4.7
Rv3131   conserved hypothetical protein 4.01 0.273 1.66 0.189 2.4
Rv3132c dosS sensor histidine kinase 2.00 0.014 0.18 0.001 11.0
Rv3133c dosR two-component response regulator 1.00 0.070 0.22 0.009 4.5
Rv3134c   conserved hypothetical protein 2.45 0.024 0.16 0.002 15.0
Rv3841 bfrB bacterioferritin 1.22 0.106 1.36 0.087 0.9
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BMC Microbiology

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