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Table 3 Characteristics of bla locus alleles

From: Evidence for a purifying selection acting on the β-lactamase locus in epidemic clones of methicillin-resistant Staphylococcus aureus

Gene Allele No. Frequency SNPc) Amino acid substitutions
   MRSAa) MSSAb)   Silent Conservative Missense Nonsense
  1 0.43 0.21 0 0 0 0 0
  2 0.02 0 1 0 0 1 1
  3 0.07 0.04 9 4 2 2 0
  4 0.04 0 9 4 2 3 0
  5 0.06 0 7 2 2 3 0
  6 0.11 0.46 13 8 2 3 0
blaZ 7 0.02 0 12 6 2 4 0
  8 0.10 0.04 11 6 2 3 0
  9 0.07 0.08 20 9 2 7 0
  10 0.04 0.04 19 8 2 7 0
  11 0.06 0.04 24 11 3 8 0
  12 0 0.04 24 11 2 8 0
  13 0 0.04 12 7 2 3 0
  1 0.33 0.45 0 0 0 0 0
  2 0.15 0.25 6 5 0 1 0
  3 0.19 0.15 1 0 0 1 0
  4 0.19 0.05 4 3 0 1 0
blaI 5 0.04 0 7 5 0 2 0
  6 0.07 0 4 3 0 1 0
  7 0.04 0 5 4 0 1 0
  8 0 0.05 3 1 1 1 0
  9 0 0.05 1 0 0 1 0
  1 0.26 0.24 0 0 0 0 0
  2 0.07 0 19 9 4 6 0
  3 0.10 0 18 7 4 6 0
  4 0.07 0.06 35 15 9 10 0
  5 0.07 0.18 35 15 7 11 0
  6 0.07 0.12 17 6 4 6 0
blaR1 7 0.07 0.06 24 10 7 7 0
  8 0.03 0 33 12 6 12 0
  9 0.16 0 31 11 6 11 0
  10 0.13 0.24 32 12 6 11 0
  11 0 0.06 20 9 5 7 0
  12 0 0.06 34 16 6 10 0
  1. a) The total number of MRSA strains whose blaZ, blaI and blaR1 genes were analyzed is 54, 27 and 31, respectively.
  2. b) The total number of MSSA strains whose blaZ, blaI and blaR1 genes were analyzed is 24, 20 and 17, respectively.
  3. c) For each allele, the SNP were counted taking as reference Tn552 bla sequences (allele 1).