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Table 2 Comparison of bacterial composition from inflamed and non-inflamed tissue within individual IBD patients using ∫-LIBSHUFF, unweighted and weighted UniFrac, the parsimony P-test and RDP Library Compare.

From: High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

 

Crohn's Disease Patients

Ulcerative Colitis Patients

 

CD1

CD2

CD3

CD4

CD5

CD6

UC1

UC2

UC3

UC4

UC5

UC6

∫-LIBSHUFF

*

**

**

n/s

*

n/s

*

*

***

**

*

**

UW UniFrac

***

***

***

n/s

***

***

***

***

**

***

***

***

W UniFrac

**

***

n/s

***

*

n/s

n/s

***

***

**

n/s

*

P-Test

***

***

***

***

***

***

***

***

***

***

***

***

Library Compare

Firmicutes

↑**

↑***

 

↓***

    

↑***

   

>Clostridiales

 

↑***

 

↓***

    

↑***

   

>>Lachnospiraceae

 

↑***

 

↓***

        

>>Ruminococcaceae

         

↓**

  

Bacteroidetes

↓**

↓***

 

↑***

    

↓***

   

>>>Bacteroides

 

↓***

          

>>>Parabacteroides

↓**

           

>>>Prevotella

   

↑***

   

↑***

↓***

   

Actinobacteria

         

↑**

  

>>>Collinsella

         

↑**

  

Proteobacteria

   

↓***

        

>>>Sutterella

   

↓***

        

Fusobacteria

    

↑*

       

>>>Fusobacterium

    

↑*

       
  1. Key:- *** = P < 0.001, ** = P < 0.01, * = P < 0.05, n/s = P > 0.05. ↑ = Increased in inflamed vs. non-inflamed tissue, ↓ = Decreased in inflamed vs. non-inflamed tissue. Bold = Phylum level classification, > = Order level classification, >> = Family level classification, >>> = Genus level classification.