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Table 2 Association between number of CagA EPIYA C motifs and H. pylori-associated diseases

From: Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer

  Univariate analysis Multivariate analysis
  p OR 95% CI p
Gastric cancer     
   - Increasing age < 10-3 1.04 1.03 - 1.06 < 10-3
   - Female sex < 10-3 0.29 0.18 - 0.48 < 10-3
   - High-risk EPIYA (ABCC or ABCCC) < 10-3 3.08 1.74 - 5.45 < 10-3
Duodenal ulcer     
   - Increasing age < 10-3 1.03 1.02 - 1.05 < 10-3
   - Female sex 0.04 1.26 0.73 - 2.18 0.41
   - High-risk EPIYA (ABCC or ABCCC) 0.29 - - -
  1. The Hosmer-Lemeshow test showed good fitness of the model of gastric cancer (8 degrees of freedom, p = 0.86, with 10 steps) and duodenal ulcer (8 degrees of freedom, p = 0.25, with 10 steps).
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BMC Microbiology

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