Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium

BMC Microbiology

Table 3 Classification of ArcA regulated genes according to Clusters of Orthologous Groups (COGs)

Functional Gene Groups^a	# of Genes^b
	ArcA-activated	ArcA-repressed
Cell division and chromosome partitioning	0	0
Cell envelope and biogenesis, outer membrane	4	4
Cell motility and secretion	1	12
Posttranslational modification, protein turnover, chaperones	1	3
Inorganic ion transport and metabolism	1	12
Signal transduction mechanisms	5	3
Cellular processes ^c	12	34
Defense Mechanisms ^c	1	1
Translation, ribosomal structure, and biogenesis	0	7
Transcription	8	18
DNA replication, recombination, and repair	2	4
Information storage and processing ^c	10	29
Intracell trafficking ^c	0	1
Energy production and conversion	9	18
Amino acid transport and metabolism	25	30
Nucleotide transport and metabolism	7	2
Carbohydrate transport and metabolism	20	16
Coenzyme metabolism	0	2
Lipid metabolism	1	7
Secondary metabolites biosynthesis, transport, and catabolism	12	4
Metabolism ^c	74	79
General function prediction only	8	21
Function unknown	8	24
Poorly characterized	23	67
Unknown ^c	39	112
Total	147	245

^aThe differentially expressed genes were classified according to clusters of orthologous groups (COGs) as defined at http://www.ncbi.nlm.nih.gov/COG.
^bNumber of genes activated or repressed (by having a ratio ≥ ± 2.5-fold) by ArcA.
^cBolded functional gene catagories contain a summary of the unbolded COG functional gene groups that are located in each of the previous lines.

ISSN: 1471-2180