Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata

BMC Microbiology

Table 1 Antibacterial activity of boswellic acid molecules against bacterial pathogens.

Organisms (CIⁿ)		KBA	AKBA	BA	ABA
	Ciprofloxacin	MIC^a	MIC^a	MIC^a	MIC^a	MBC^b
S. aureus ATCC-29213	0.25	16	2	32	>128	>128
MRSA ATCC 3591, (50)	8->16	16-32	2-4	32-64	>128	>128
E. faecalis ATCC 29212, (22)	0.25-16	16-32	4-8	8-16	>128	>128
E. faecium ATCC 8042, (18)	0.25-16	16-32	4-8	8-16	>128	>128
S. epidermidis ATCC 12228,(12)	0.25->16	8-16	4-8	32-64	>128	>128
Vancomycin resistant E. faecalis (10)	>16	8-16	2-8	8-16	>128	>128
E. coli ATCC 25292	0.03	>128	>128	>128	>128	>128
P. aeruginosa ATCC 27853	0.12	>128	>128	>128	>128	>128

MICs and MBCs of boswellic acid molecules were determined using CLSI guidelines against 115 clinical isolates including ATCC strains. ^aMinimum Inhibitory Concentration (μg/ml); ^bMinimum Bactericidal Concentration (μg/ml); CI = Clinical isolates; n = number of clinical isolates.

ISSN: 1471-2180