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Table 2 Cytokine secretion by PMA-differentiated U937 macrophages following stimulation with S. suis P1/7 and its SspA deficient mutant G6G.

From: The SspA subtilisin-like protease of Streptococcus suis triggers a pro-inflammatory response in macrophages through a non-proteolytic mechanism

Strain Amount secreted of cytokines (pg/ml)
  IL-1β TNF-α IL-6 CXCL8 CCL5
Control 51 ± 3 217 ± 2 10 ± 1 5245 ± 432 2116 ± 4
S. suis P1/7 161 ± 8 1800 ± 11 1160 ± 21 611000 ± 756 13355 ± 564
S. suis G6G 120 ± 3* 1030 ± 14* 690 ± 6* 653000 ± 634* 15664 ± 34*
  1. The data are the means ± SD of triplicate assays for three separate experiments. Asterisks indicate a significant difference in cytokine secretion by macrophages stimulated with the SspA deficient mutant (G6G) in comparison with the parental strain at P < 0.01.