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Table 2 Cytokine secretion by PMA-differentiated U937 macrophages following stimulation with S. suis P1/7 and its SspA deficient mutant G6G.

From: The SspA subtilisin-like protease of Streptococcus suis triggers a pro-inflammatory response in macrophages through a non-proteolytic mechanism

Strain

Amount secreted of cytokines (pg/ml)

 

IL-1β

TNF-α

IL-6

CXCL8

CCL5

Control

51 ± 3

217 ± 2

10 ± 1

5245 ± 432

2116 ± 4

S. suis P1/7

161 ± 8

1800 ± 11

1160 ± 21

611000 ± 756

13355 ± 564

S. suis G6G

120 ± 3*

1030 ± 14*

690 ± 6*

653000 ± 634*

15664 ± 34*

  1. The data are the means ± SD of triplicate assays for three separate experiments. Asterisks indicate a significant difference in cytokine secretion by macrophages stimulated with the SspA deficient mutant (G6G) in comparison with the parental strain at P < 0.01.