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Table 1 Antimicrobial susceptibility, QRDR mutations and sequence types of quinolone-resistant E. coli isolates

From: Quinolone resistance in Escherichia coli from Accra, Ghana

Strains Nali-dixic acid MIC
mg/L
Resistance pattern* QRDR mutations Horizontally acquired quinolone resistance genes Allelic profile Sequence type (ST) ST complex
    Δ GyrA Δ ParC   adk fumC gyrB icd mdh purA recA   
2006               
06/073 64 AC NSLTR none none none 6 19 15 16 9 8 7 443 205
06/079 128 AC NSLTR none none none 6 65 2 25 5 5 2 1466 none
06/137 128 AC NSLTR none none none 6 65 2 25 5 5 2 1466 none
06/065 128 A NSLTR none none qnrS1 6 7 5 1 8 18 2 206 206
06/036 256 AC NSLTR none none none 6 8 4 1 9 48 7 210 none
06/027 64 C N S83L none qnrB2 10 11 4 8 8 8 2 10 10
06/045 64 A NSLTR S83L none none 10 174 4 8 8 8 2 1286 10
06/056 128 A NSLTR S83L none none 112 11 5 12 8 8 86 542 none
06/068 128 AC NSLTR S83L none none 76 43 19 37 30 1 2 1465 none
06/151 >1024 ACPNSLTR S83L, D87N none none 43 41 15 18 11 7 6 101 101
06/154 >1024 ACPN TR S83L, D87N none qnrB1 43 41 15 18 11 7 6 101 101
06/030 >1024 ACPN LTR S83L, D87N S80I qnrS1 10 11 4 8 8 13 73 617 10
06/110 >1024 ACPNSLTR S83L, D87N S80I none 92 4 87 96 70 58 2 648 none
06/148 >1024 A PNSLTR S83L, D87N S80I none 92 4 87 96 70 58 2 648 none
06/026 >1024 ACPNSLTR S83L, D87N S80I, N105S none 56 6 22 16 11 1 7 455 None
06/112 >1024 ACPN LTR S83L, D87N S80I, E84K none 6 29 32 16 11 8 44 156 156
2007      none          
07/16a 256 A PNSLT none none none 6 95 4 18 11 7 14 1304 none
07/34 128 AC N LTR none none none 10 11 4 12 7 8 2 1467 none
07/12 64 NSLT S83L none none 10 11 4 8 8 8 2 10 10
07/37 128 A N L R S83L T66I none 10 11 4 8 8 8 2 10 10
07/SHA >1024 A PNSLTR S83L, D87N none none 6 11 95 104 8 7 2 450 none
07/375 >1024 A PNSLTR S83L, D87N S80I qepA 10 11 4 8 8 8 2 10 10
07/337 >1024 A PN LTR S83L, D87N S80I none 10 11 4 8 8 8 2 10 10
07/282 >1024 ACPNSLTR S83L, D87N E84K qepA 6 29 32 16 11 8 44 156 156
07/24A >1024 ACPNSLTR S83L, D87N S80I, E84G qnrB1 85 88 78 29 59 58 62 354 354
2008               
08/54 64 AC NSLTR none none none 6 99 22 1 8 7 2 1479 206
08/23 64 ACPNSLTR none none none 10 29 4 8 8 8 44 1473 156
08/43 128 A NSLTR none none none 6 7 14 1 8 18 2 1471 l206
08/33 >1024 ACPNSLTR none none qnrS1 6 11 14 8 8 6 6 1469 None
08/91 >1024 ACPNSLTR none none none 10 11 4 1 8 9 2 227 10
08/101 64 A NSLTR S83A none qnrS1 10 11 4 1 8 9 2 227 10
08/78 128 ACPNSLTR S83L none qnrS1 10 11 4 8 8 8 2 10 10
08/90 256 ACPNSLTR S83L, D87N S80I none 6 4 12 1 20 18 7 410 23
08/11 >1024 A PNSLTR S83L, D87N S80I none 6 6 5 26 11 8 6 1468 none
08/26 >1024 A PN LTR S83L, D87N S80I qnrS1 10 11 4 8 8 8 2 10 10
08/87 >1024 A NSLTR S83L, D87N S80I none 10 11 4 8 8 8 2 10 10
08/84 >1024 A NSLTR S83L, D87N S80I qnrS1 10 11 4 8 8 8 2 10 10
08/93 >1024 A PNSLTR S83L, D87N S80I none 10 11 4 8 8 8 2 10 10
08/17 >1024 ACPNSLTR S83L, D87N S80I, E84V none 53 40 47 13 36 28 29 131 none
08/39 >1024 ACPNSLTR S83L, D87N S80I, A108V none 92 40 87 96 70 8 29 1470 none
  1. *A = Ampicillin, C = Chloramphenicol, P = Ciprofloxacin, N = Nalidixic acid, S = Streptomycin, L = Sulphonamide, T = Tetracycline R = Trimethoprim