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Table 2 Polymorphisms in the genes of mce4 operon.

From: Single nucleotide polymorphism in the genes of mce1 and mce4 operons of Mycobacterium tuberculosis: analysis of clinical isolates and standard reference strains

mce4operon

Gene Name

(Accession Number)

Nucleotide Change

[GenBank Accession Number]

Amino Acid Change

Frequency Distribution of polymorphism

(%)

  

Non Synonymous

Synonymous

All isolates

n = 112

DS

n = 22

DR

n = 59

SDR

n = 15

MDR TB

n = 19

yrbE4A

[Rv3501c]

G18T

C753A

[GenBank: HQ901084]

NONE

Ala6Ala

Ile251Ile

(25.49)

(20.83)

(29.62)

(41.76)

(21.05)

yrbE4B

[Rv3500c]

C21T

C624T

[GenBank: HQ901090]

NONE

Ile7Ile

Pro208Pro

(3.7)

(8)

(3.44)

(5.88)

NONE

mce4A

[Rv3499c]

T32G

C873T

[GenBank: HQ901091]

Val11Gly

Phe291Phe

(2.25)

(4.55)

NONE

NONE

NONE

mce4B

[Rv3498c]

NONE

NONE

NONE

NONE

NONE

NONE

NONE

NONE

mce4C

[Rv3497c]

A136C

C571A

[GenBank: HQ901092]

Thr46Pro

Arg191Ser

NONE

(3.75)

(8.33)

NONE

(5.88)

(5.26)

mce4D

[Rv3496c]

G35A

[GenBank: HQ901093]

Arg12Gln

NONE

(1.25)

(7.69)

NONE

NONE

NONE

lprN

[Rv3495c]

C798T

C1016A

[GenBank: HQ901094]

Thr339Lys

Ala266Ala

(26.47)

(29.09)

(30.9)

(31.57)

(31.07)

mce4F

[Rv3494c]

C117A

C1214T

[GenBank: HQ901087]

Pro405Lys

Thr39Thr

(8.75)

(9.09)

(7.3)

(10.52)

(5.09)

  1. Frequency of single nucleotide polymorphisms detected in the genes of mce4 operon. The nucleotide changes and the corresponding changes in amino acids are shown here. The frequency of SNPs was calculated from 112 clinical isolates. The data has been subdivided according to the drug susceptibility profile.
  2. The single letter nucleotide designations used are as follows: A, adenine; C, cytosine; G, guanine and T, thymidine. The three letter amino acid designations used are as follows Ala, alanine; Ile, isoleucine; Pro, proline; Val, valine; Gly, glycine; Phe, phenylalanine; Thr, threonine; Arg, arginine; Ser; serine; Gln, glutamine and Lys, lysine.
  3. DS: drug sensitive, DR: drug resistant, SDR: single drug resistant, MDR TB: Multi drug resistant