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Table 1 Candida isolates used in this study and their susceptibility to antifungals and interactions with G. mellonella

From: Oral Candida albicans isolates from HIV-positive individuals have similar in vitro biofilm-forming ability and pathogenicity as invasive Candida isolates

Microorganisms Susceptibility to Antifungal (MIC) Galleria mellonella
Specie of
Candida
Strain of
Candida
Clinical
isolate
Fluconazole
(μg/mL)
Amph B
(μg/mL)
CFU/larva
injected
Number of killing/total Medium time to mortality (h)
C. albicans 4S Saliva 0.125 0.25 7.1 × 105 16/16 18
  10S Saliva 0.125 0.5 5.2 × 105 16/16 18
  24S Saliva 0.125 0.5 9.4 × 105 16/16 18
  31S Saliva 0.125 0.5 5.0 × 105 16/16 24
  39S Saliva Resistant 0.25 5.9 × 105 16/16 18
  48S Saliva 0.125 0.25 6.7 × 105 16/16 18
  60S Saliva 0.125 0.25 6.3 × 105 16/16 18
  3 OPC 0.5 0.25 7.2 × 105 16/16 18
  14 OPC Resistant 0.25 5.7 × 105 16/16 18
  21 OPC Resistant 0.25 7.5 × 105 16/16 18
  37 OPC Resistant 0.25 5.5 × 105 16/16 18
  CAL006 Blood culture 0.125 0.5 1.9 × 105 16/16 24
  CAL007 Peritoneal fluid 2 0.25 4.5 × 105 16/16 24
  CAL008 Peritoneal fluid 1 0.5 7.2 × 105 16/16 18
  CAL009 Blood culture 1 0.5 4.7 × 105 16/16 18
  CAL010 Subdiaphragnatic 1 0.5 4.8 × 105 16/16 18
C. tropicalis 12 OPC 0.5 0.25 3.9 × 105 16/16 18
  140S Saliva 0.125 0.25 4.9 × 105 16/16 18
  CTR002 Synovial fluid Resistant 0.5 9.1 × 105 16/16 18
  CTR003 Abdominal fluid 2 0.5 5.0 × 105 16/16 18
C. parapsilosis 127S Saliva 1 0.5 6.2 × 105 16/16 18
  CPA001 Lung tissue 4 0.5 7.3 × 105 16/16 21
C. glabrata 12S Saliva 2 0.5 6.4 × 105 2/16 -
  45 OPC 4 0.5 9.8 × 105 6/16 -
  55 OPC 4 0.5 1.0 × 106 0/16 -
  CGL002 Drainage 32 0.5 4.0 × 105 0/16 -
  CGL003 Jackson-Pratt fluid 32 0.5 5.4 × 105 8/16 -
C. dubliniensis 18S Saliva 16 0.25 3.9 × 105 16/16 18
  155S Saliva 0.5 0.25 5.1 × 105 16/16 18
C. lusitaniae CLU005 Blood culture 2 1 1.4 × 105 14/16 -
C.norvegensis 52S Saliva 32 0.5 6.3 × 105 6/16 -
C. krusei 58 OPC Resistant 2 8.8 × 105 4/16 -
C. kefyr CKE002 Blood culture 2 1 4.2 × 105 2/16 -