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Table 2 Analysis of the human host-flavivirus protein-protein interaction network

From: Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen

Nb of targeting viruses

Nb of targeted human proteins

Targeted human proteins

4

2 (1.7%)

APBB1IP, ENO1

3

10 (8.3%)

ARID2, AZI2, CAMTA2, CEP63, MLPH, MYH9, NME3, TAF15, TRAF4, VPS11

2

26 (21.7%)

ARNTL, BCL2L14, CCDC99, CEP250, DNTTIP2, FAM184A, GGA1, GRN, JAG1, LAMB2, NFKBIA, OPTN, PABPC1, PDE4DIP, PHC2, PHLDB3, PIAS3, RNF125, RNUXA, SCRIB, SNRPA, TOM1L1, TRIM21, TXNDC9, VIM, ZBTB17

1

82 (68.3%)

-

  1. We determined the number of flavivirus species that interact with each cellular host protein found to be targeted by NS3 or NS5 (Y2H plus literature).