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Table 1 P. aeruginosa genes with enhanced expression at pH 7.5 vs pH 6.0

From: Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosacan be achieved without iron provision by maintaining local phosphate abundance: role of pH

PA ID

Gene name

Fold expression pH7.5 vs pH6.0

Regulon

Function

Subsystem

PA1134

 

2.58

IS

probable membrane protein

 

PA1148

toxA

2.33

IS

exotoxin A precursor

 

PA2384

 

4.78

 

Hypothetical protein in pyoverdin gene cluster/Fe2+/Zn2+ uptake regulation proteins

Siderophore_Pyoverdine

PA2385

pvdQ

2.56

FUR

Acyl-homoserine lactone acylase PvdQ (EC 3.5.1.-), quorum-quenching

Siderophore_Pyoverdine

PA2386

pvdA

2.99

IS

L-ornithine 5-monooxygenase (EC 1.13.12.-), PvdA of pyoverdin biosynthesis

Siderophore_Pyoverdine

PA2389

pvdR

2.36

IS

pyoverdine-specific efflux macA-like protein

Siderophore_Pyoverdine

PA2390

pvdT

2.01

IS

Pyoverdine efflux carrier and ATP binding protein

Siderophore_Pyoverdine

PA2391

opmQ

1.86

IS

Outer membrane pyoverdine eflux protein

Siderophore_Pyoverdine

PA2392

pvdP

2.98

IS

Pyoverdine biosynthesis related protein PvdP, Twin-arginine translocation pathway signal domain

Siderophore_Pyoverdine

PA2393

pvdM

3.43

IS

Putative dipeptidase, pyoverdin biosynthesis PvdM

Siderophore_Pyoverdine

PA2394

pvdN

3.24

IS

Pyoverdin biosynthesis protein PvdN, putative aminotransferase, class V

Siderophore_Pyoverdine

PA2395

pvdO

2.00

IS

PvdO, pyoverdine responsive serine/threonine kinase

Siderophore_Pyoverdine

PA2396

pvdF

2.53

IS

Pyoverdine synthetase PvdF, N5-hydroxyornithine formyltransferase

Siderophore_Pyoverdine

PA2397

pvdE

3.16

IS

PvdE, pyoverdine ABC export system, fused ATPase and permease components

Siderophore_Pyoverdine

PA2398

fpvA

4.07

IS

Outer membrane ferripyoverdine receptor FpvA, TonB-dependent

Siderophore_Pyoverdine

PA2399

pvdD

3.62

IS

Pyoverdine sidechain non-ribosomal peptide synthetase PvdD

Siderophore_Pyoverdine

PA2400

pvdJ

3.84

IS

Pyoverdine sidechain non-ribosomal peptide synthetase PvdJ

Siderophore_Pyoverdine

PA2402

pvdI

4.22

IS

Pyoverdine sidechain non-ribosomal peptide synthetase PvdI

Siderophore_Pyoverdine

PA2403

 

4.62

 

Putative iron-regulated membrane protein

Siderophore_Pyoverdine

PA2404

 

4.96

 

Putative thiamine pyrophosphate-requiring enzyme

Siderophore_Pyoverdine

PA2405

 

5.71

 

Hypothetical protein in pyoverdin gene cluster

Siderophore_Pyoverdine

PA2406

 

3.84

 

Hypothetical protein in pyoverdin gene cluster

Siderophore_Pyoverdine

PA2407

 

2.34

 

Cation ABC transporter, periplasmic cation-binding protein, PA2407 homolog

Siderophore_Pyoverdine

PA2408

 

2.82

 

ABC transporter in pyoverdin gene cluster, ATP-binding component

Siderophore_Pyoverdine

PA2409

 

1.69

 

ABC transporter in pyoverdin gene cluster, permease component

Siderophore_Pyoverdine

PA2410

 

1.84

 

ABC transporter in pyoverdin gene cluster, periplasmic component

Siderophore_Pyoverdine

PA2411

 

2.98

IS

Probable thioesterase involved in non-ribosomal peptide biosynthesis, PA2411 homolog

Siderophore_Pyoverdine

PA2412

 

3.12

IS

Hypothetical MbtH-like protein

Siderophore_Pyoverdine

PA2413

pvdH

3.04

IS

Pyoverdin biosynthesis protein PvdH, L-2, 4-diaminobutyrate:2-oxoglutarate aminotransferase

Siderophore_Pyoverdine

PA2424

pvdL

3.20

IS

Pyoverdine chromophore precursor synthetase PvdL

Siderophore_Pyoverdine

PA2425

pvdG

4.07

IS

Thioesterase PvdG involved in non-ribosomal peptide biosynthesis

Siderophore_Pyoverdine

PA2426

pvdS

5.21

FUR

Sigma factor PvdS, controling pyoverdin biosynthesis

Siderophore_Pyoverdine

PA2427

 

6.13

IS

Hypothetical protein PvdY

Siderophore_Pyoverdine

PA4168

fpvB

2.03

 

Outer membrane ferripyoverdine receptor FpvB, for Type I pyoverdine

Siderophore_Pyoverdine

PA5150

 

2.44

IS

probable short-chain dehydrogenase

 

PA0471

fluR

2.75

FUR

probable transmembrane sensor

 

PA0472

fluI

2.59

FUR

probable sigma-70 factor, ECF subfamily

 

PA0672

hemO

3.61

FUR

Heme oxygenase HemO, associated with heme uptake

Hemin_transport_system

PA2467

foxR

2.08

FUR

Fe2+-dicitrate sensor, membrane component

 

PA2468

foxI

2.86

FUR

probable sigma-70 factor, ECF subfamily

 

PA4227

pchR

4.73

FUR

Transcriptional regulator PchR

Siderophore_pyochelin

PA4467

 

7.46

FUR

Metal transporter, ZIP family

 

PA4468

sodM

5.59

FUR

Manganese superoxide dismutase (EC 1.15.1.1)

 

PA4469

 

10.90

FUR

FOG: TPR repeat

 

PA4470

fumC1

7.91

FUR

Fumarate hydratase class II (EC 4.2.1.2)

TCA_Cycle

PA4471

 

7.01

FUR

FagA protein

 

PA4515

 

2.80

FUR

Iron-uptake factor PiuC

Transport_of_Iron

PA4516

 

1.87

FUR

FOG: TPR repeat, SEL1 subfamily

 

PA4708

phuT

2.00

FUR

Heme-transport protein, PhuT

Hemin_transport_system

PA4709

 

2.22

FUR

probable hemin degrading factor

Hemin_transport_system

PA4710

phuR

2.00

FUR

Haem/Haemoglobin uptake outer membrane receptor PhuR precursor

Ton_and_Tol_transport_systems

PA4895

 

1.47

FUR

Iron siderophore sensor protein

Iron_siderophore_sensor_&_receptor_system

PA4896

 

3.14

FUR

probable sigma-70 factor, ECF subfamily

Iron_siderophore_sensor_&_receptor_system

PA1911

femR

3.55

 

sigma factor regulator, FemR

 

PA1912

femI

5.53

 

ECF sigma factor, FemI

 
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BMC Microbiology

ISSN: 1471-2180

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