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Table 1 Description of 45 monozygotic twin pairs discordant for chronic impairing fatigue.

From: An unbiased metagenomic search for infectious agents using monozygotic twins discordant for chronic fatigue

Variable Affected twins Unaffected co-twins Statistical comparison
Met criteria for chronic fatigue syndrome 32/45, 71% 0/45, 0% By design
Met criteria for idiopathic chronic fatigue 13/45, 29% 0/45, 0% By design
Female sex 40/45, 89% 40/45, 89% Identical by design
Median age at evaluation, IQR 51, 39-59 years 51, 39-59 years Identical by design
Median body mass index, IQR 25, 22-30 kg/m2 24, 22-31 kg/m2 Paired t44 = 0.1, p = 0.91
Median SF-36 physical function, IQR 41, 27-48 48, 39-52 Paired t44 = 3.1, p = 0.003
Median SF-36 mental function, IQR 39, 29-48 51, 39-56 Paired t44 = 4.7, p = 3 × 10-5
Median current fatigue by VAS, IQR 69, 49-77 19, 10-51 Paired t43 = -7.2, p = 6 × 10-9
  1. Abbreviations: IQR = inter-quartile range, VAS = visual analogue scale (0-100).