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Table 1 Cytokine producing cells isolated from Peyer's patches of mice untreated or treated with L. casei CRL 431 previous and post challenge with S. Typhimurium

From: Oral administration of a probiotic Lactobacillus modulates cytokine production and TLR expression improving the immune response against Salmonella enterica serovar Typhimurium infection in mice

Experimental groups N° of cytokine secreting cells
  TNFα IFNγ IL-10
C 10 ± 4a 13 ± 3ad 12 ± 3a
Lc 24 ± 9b 20 ± 3b 17 ± 1b
S 26 ± 4b 16 ± 1ab 22 ± 6b
Lc-S 36 ± 12b 12 ± 2d 9 ± 4a
Lc-S-Lc 75 ± 4c 41 ± 10c 13 ± 5a,b
  1. Cytokine producing cells were analyzed by immunocytochemistry in mononuclear cells isolated from Peyer's patches of mice at 2 time points: the day of the infection (basal data) for the untreated control (C) and for mice given L. casei CRL 431 during 7 days (Lc), and 7 days post infection for infection control (S), mice given probiotic 7 days before the infection (Lc-S), and mice given continuously probiotic, before and after infection (Lc-S-Lc). Results for healthy mice obtained the same day of the infected animals were not added because there were not significant differences compared to the basal data. Results are expressed as the means ± SD of the total number of positive cells per 2 × 104 counted cells at 1 000X magnification. Means for each value without a common letter differ significantly (P < 0.01).