Genbank accession no. | Genes/ORF | Description | Expression ratio mutant/WT | P-valueb | Functions | References | |
---|---|---|---|---|---|---|---|
 |  |  | Microarraya | RT-qPCR |  |  |  |
Autolysis-related genes | Â | Â | Â | ||||
AAW52842 | lytS | two-component sensor histidine kinase LytS | 3.87 | 2.33 ± 0.35 | 0.0097 | Negatively modulating the expression of murein hydrolases and positively regulates the expression of the lrgAB operon in S. aureus | |
AAW52844 | lrgA | holin-like protein LrgA | 2.28 | 2.75 ± 0.05 | < 0.0001 | Encoding a murein hydrolase exporter similar to bacteriophage holin proteins; may be required for the activity or transport of this cell wall-associated murein hydrolase in S. aureus | [44] |
AAW53428 | serp0043 | 1,4-beta-N-acetylmuramidase | 4.86 | 2.25 ± 0.20 | 0.0016 | Having lysozyme activity in peptidoglycan catabolic process in S. aureus | [14] |
AAW53918 | glpQ | glycerophosphoryl diester phosphodiesterase GlpQ, putative | 2.98 | 1.80 ± 0.20 | 0.0080 | Having glycerophosphodiester phosphodiesterase activity in lipid and glycerol metabolic process in S. aureus | [55] |
AAW54343 | arlR | DNA-binding response regulator | 8.30 | 3.20 ± 0.45 | 0.0015 | Regulating extracellular proteolytic activity; may be involved in the modulation of expression of genes associated with growth and cell division; positively regulating a two-component system lytRS in S. aureus | |
AAW53968 | atlE | S. epidermidis autolysin | UDc | 1.45 ± 0.10 | 0.0053 | Having amidase activity to cleave the amide bond between N-acetyl muramic acid and L-alanine; mediating lysis of a subpopulation of the bacteria and extracellular DNA release in S. epidermidis | |
AJ250905 | aae | S. epidermidis autolysin/adhesin | UD | 2.32 ± 0.38 | 0.0088 | Having bacteriolytic activity and binding to fibrinogen, fibronectin and vitronectin in S. epidermidis | [8] |
Biofilm-forming related genes | Â | Â | Â | ||||
AAW53175 | icaA | a gene of ica operon | UD | 1.22 ± 0.13 | 0.20 | Encoding N-acetyglucosaminyltransferase for synthesis of polysaccharide intercellular adhesin (PIA) which is important for biofilm formation of S. epidermidis | |
AAW53239 | aap | accumulation-associated protein | UD | 1.62 ± 0.06 | 0.0008 | Contributing to intercellular adhesion and biofilm formation of S. epidermidis | |
sae operon | Â | Â | Â | ||||
AAW53762 | saeS | sensor histidine kinase SaeS | 0.26 | UD | Â | Encoding a histidine kinase; involving in the tight temporal control of virulence factor expression in S. aureus | |
AAW53763 | saeR | DNA-binding response regulator SaeR | 0.14 | UD | Â | The response regulator SaeR binding to a direct repeat sequence in S. aureus; involving in anaerobic growth and nitrate utilization in S. epidermidis | |
AAW53764 | saeQ | conserved hypothetical protein | UD | UD | Â | Encoding a membrane protein, function unknown in S. epidermidis | [62] |
AAW53765 | saeP | lipoprotein, putative | UD | UD | Â | Encoding a lipoprotein, function unknown in S. epidermidis | [62] |