Figure 5

MAPK phosphorylation in HKs exposed to BCM or PCM. MAPK phosphorylation in HKs exposed to PCM or BCM for 4 or 24 hours. p38 (A) and JNK (B) phosphorylation levels were decreased in BCM treated HKs after 4 and 24 hours of exposure to BCM while PCM induced p38 and JNK phosphorylation after 24 hours. ERK phosphorylation (C) was unchanged in PCM treated HKs and increased in BCM treated HKs. Results represented as mean ± SD, n = 6, *p < 0.05, **p < 0.01 relative to control cells.