TY - JOUR AU - Sjögren, Jonathan AU - Okumura, Cheryl YM AU - Collin, Mattias AU - Nizet, Victor AU - Hollands, Andrew PY - 2011 DA - 2011/05/27 TI - Study of the IgG endoglycosidase EndoS in group A streptococcal phagocyte resistance and virulence JO - BMC Microbiology SP - 120 VL - 11 IS - 1 AB - The secreted enzyme EndoS, an endoglycosidase from Streptococcus pyogenes, hydrolyzes the N-linked glycan of the constant region of immunoglobulin G (IgG) heavy chain and renders the antibody unable to interact with Fc receptors and elicit effector functions. In this study we couple targeted allelic replacement mutagenesis and heterologous expression to elucidate the contribution of EndoS to group A Streptococcus (GAS) phagocyte resistance and pathogenicity in vitro and in vivo. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-11-120 DO - 10.1186/1471-2180-11-120 ID - Sjögren2011 ER -