TY - JOUR AU - Im, Hookang AU - Sharpe, Miriam L. AU - Strych, Ulrich AU - Davlieva, Milya AU - Krause, Kurt L. PY - 2011 DA - 2011/05/25 TI - The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design JO - BMC Microbiology SP - 116 VL - 11 IS - 1 AB - Streptococcus pneumoniae is a globally important pathogen. The Gram-positive diplococcus is a leading cause of pneumonia, otitis media, bacteremia, and meningitis, and antibiotic resistant strains have become increasingly common over recent years.Alanine racemase is a ubiquitous enzyme among bacteria and provides the essential cell wall precursor, D-alanine. Since it is absent in humans, this enzyme is an attractive target for the development of drugs against S. pneumoniae and other bacterial pathogens. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-11-116 DO - 10.1186/1471-2180-11-116 ID - Im2011 ER -