Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus

Table 2 EC50s of AMPs against S. aureus

Antimicrobial Peptides	Molecular weight (g/mol)	EC50 (μg/ml)	95% CI	EC50 (μM)
NA-CATH	5885.50	2.85	1.22-6.69	0.48
NA-CATH-ATRA1-ATRA1	5977.60	0.51	0.25-1.01	0.09
ATRA-1	2409.06	0.52	0.25-1.11	0.22
ATRA-2	2316.96	18.0	7.67-41.8	7.77
ATRA-1A	2332.96	0.73	0.33-1.62	0.31
LL-37	5177.42	1.27	0.44-3.72	0.25
D-LL-37	5177.42	12.7	6.48-24.9	2.45

This table indicates the EC50 of the peptides against S. aureus in an anti-microbial assay. (*) The molecular weight reported here for each peptide reflects the TFA salts of the peptides. These molecular weights were then used to convert the EC50 in μg/ml to μM, to enable comparisons on a molecule by molecule basis.

ISSN: 1471-2180