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Table 7 Genes with positively selected amino-acid changes between the East Asian and the European H. pylori

From: Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pyloriEast Asian genomes

Locus tag

Gene

Description

p-value(a)

Positively selected sites (b,c)

HP0547

cagA

Cag pathogenicity island protein

< 1E-21

V238R (0.994)

    

A482Q (0.953)

HP0373

homC

Putative outer membrane protein

< 1E-14

E110N (0.978)

    

K428H (0.986)

    

T437D (0.979)

HP0492

hpaA-2

Hpa paralog

< 1E-5

S34V (0.970)

    

A46Q (0.993)

    

R122F (0.967)

    

K127S (0.962)

HP1185

sotB

Sugar efflux transporter protein

0.00005

T50S (0.956)

    

A57L (0.990)

    

N134G (0.983)

    

W186Y (0.980)

mHP0174

 

Hypothetical protein

0.0007

F144W (0.952)

mHP1415

miaA

General tRNA delta(2)-isopentenylpyrophosphate transferase

0.0002

H174A (0.992)

HP0887

vacA

Vacuolating cytotoxin A

0.002(d)

S793A (0.964) (d) N931A (0.960) (d)

  1. a) Bonferonni adjusted.
  2. b) Posterior probabilities of dN/dS > 1.
  3. c) Positions are for H. pylori 26695. Residues were aligned at the same site by both Mafft [128] and PRANK [136].
  4. d) Two vacA genes (in B38 and B8) were eliminated because they belonged to different subtypes of the gene.
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BMC Microbiology

ISSN: 1471-2180

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