Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pyloriEast Asian genomes

Table 5 Selected genes diverged between East Asian (hspEAsia) and European (hpEurope) H. pylori

Function	Genes (classified by divergence within hspEAsia)
	Conserved^(a)	Average^(b)	Diverged^(c)
Known virulence genes		*vacA, tipα*	*cagA, hcpD*
Outer membrane proteins		*oipA/oipA-2, vacA, vacA-4*	*hpaA-2, homC, hopJ/hopK, horI*
Lipopolysaccharide synthesis (Lewis antigen mimicry)		*agt*	*futA/futB*
Transport		*secG* , *sotB* , *comH* , cvpA	*yajC*
Motility and chemotaxis	cheY	maf, fliT	*fliK*
Redox	fixQ	*hypD, frxA, pgl, nuoF*	*fixS, hydE*
Nuclease		rnhA	*addA, rnhB, hsdR*
Protein synthesis		*def, prmA, tilS*	*miaA*
Antibiotic-related		*def, frxA* , ftsA

Full list and details in Table 6, Additional file 5 (= Table S4) and text. Genes in bold were also extracted in the comparison of 6 hspEAsia vs. 5 hpEurope (Additional file 7 (= Table S5)).
(a) d_b<d_b*. Zone 1 in Figure 3. (b) d_b≈ d_b*. Zone 2. (c) d_b>d_b*. Zone 3.

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