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Table 3 Mutations found in M. tuberculosis (MTb) strains resistant to rifampin and isoniazid.

From: First insights into the genetic diversity of Mycobacterium tuberculosis isolates from HIV-infected Mexican patients and mutations causing multidrug resistance

Rifampin

   

Mutated

rpo B codon

Specific

mutation

Strain

n

MIC

(μg/ml)

531

TCG → TTG (Ser → Leu)a

1

>2

469

GAG → TCG (Glu → Ser)b

1

0.5

Isoniazid

   

Mutated

kat G codon

Specific

mutation

Strain

n

MIC

(μg/ml)

315

AGC → ACC (Ser → Thr)a

3

>1

315

AGC → ACC (Ser → Thr)

1

1

  1. a Mutations found in the MDR M. tuberculosis strain
  2. b Mutation not described previously
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BMC Microbiology

ISSN: 1471-2180

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