Table 2 Level of rifampicin resistance and mutations found in the rpoB gene of MRSA isolates and control strains
Genotype (ST/SCCmec/PFGE) | Rifampicin MICs (mg/L) | Number of isolates | Nucleotide mutation | Amino acid substitution |
|---|---|---|---|---|
ST228/IV-A/A | 0.012 | 5 | None | |
ST228/I/B | 2-4 | 28 | C AT→A AT | 481His→Asn |
ST228/I/B | 128 | 2 | C AT→A AT G CT→A CT | 481His→Asn 477Ala→Thr |
ST228/I/B | ≥ 256 | 1 | C AT→A AT C AA→A AA | 481His→Asn 468Gln→Lys |
ST228/I/B | ≥ 256 | 1 | C AT→A AT A TT→C TT | 481His→Asn 527Ile→Leu |
ST247/I PER88 (Iberian clone) | ≥ 256 | 1 | C AT→A AT TCA→TTA | 481His→Asn 529Ser→Leu |
ST247/I ATCCBAA44 (Iberian clone) | 2 | 1 | C AT→A AT | 481His→Asn |