Skip to main content

Table 1 Susceptibility of different Nocardia species against innate defense AMPs

From: Differential activity of innate defense antimicrobial peptides against Nocardia species

 

LD90(μg/ml)

(killing/CFU reduction in percent ± SD)

Species

levoflox

HNP 1-3

LL-37

hBD-3

indolicidin

LAP

TAP

N. farcinica ATCC 3318

8

(92.3 ± 3.8)

>32

32

(96.6 ± 0.6)

16 (92.5 ± 5.3)

16

(96.7 ± 1.7)

16

(92.9 ± 7.1)

32

(94 ± 5.1)

N. nova ATCC 33726

>32

64

(97.2 ± 3.6)

32

(91.4 ± 7.0)

16

(95.2 ± 1.7)

8

(90.5 ± 3.4)

n.d.

n.d.

N. asteroides ATCC 19247

8

(92.6 ± 3.8)

32

(90.9 ± 0.6)

>64

>64

64

(99.1 ± 0.6)

n.d.

n.d.

N. brasiliensis ATCC 19296

32

(96.6 ± 2.2)

>64

>64

>64

64

(92.9 ± 2.1)

>64

>64

  1. LD90 denotes the lowest peptide concentration leading to a = 90% reduction of CFU after incubation (12 h or 16 h) with AMPs or levofloxacin. Presented data are LD90 determinations based on means of at least four (levofloxacin, HNP 1-3, LL-37 and hBD-3) or two (indolicidin, LAP and TAP) independent sets of experiments with each Nocardia species. In brackets are means (percent CFU reduction) ± standard deviation of respective experiments.
  2. SD standard deviation, n.d. not determined