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Table 1 Susceptibility of different Nocardia species against innate defense AMPs

From: Differential activity of innate defense antimicrobial peptides against Nocardia species

  LD90(μg/ml)
(killing/CFU reduction in percent ± SD)
Species levoflox HNP 1-3 LL-37 hBD-3 indolicidin LAP TAP
N. farcinica ATCC 3318 8
(92.3 ± 3.8)
>32 32
(96.6 ± 0.6)
16 (92.5 ± 5.3) 16
(96.7 ± 1.7)
16
(92.9 ± 7.1)
32
(94 ± 5.1)
N. nova ATCC 33726 >32 64
(97.2 ± 3.6)
32
(91.4 ± 7.0)
16
(95.2 ± 1.7)
8
(90.5 ± 3.4)
n.d. n.d.
N. asteroides ATCC 19247 8
(92.6 ± 3.8)
32
(90.9 ± 0.6)
>64 >64 64
(99.1 ± 0.6)
n.d. n.d.
N. brasiliensis ATCC 19296 32
(96.6 ± 2.2)
>64 >64 >64 64
(92.9 ± 2.1)
>64 >64
  1. LD90 denotes the lowest peptide concentration leading to a = 90% reduction of CFU after incubation (12 h or 16 h) with AMPs or levofloxacin. Presented data are LD90 determinations based on means of at least four (levofloxacin, HNP 1-3, LL-37 and hBD-3) or two (indolicidin, LAP and TAP) independent sets of experiments with each Nocardia species. In brackets are means (percent CFU reduction) ± standard deviation of respective experiments.
  2. SD standard deviation, n.d. not determined