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Table 2 Putative proteins required for fungal virulence.

From: Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum

Accession no. of one EST Library Virulence determinant Function in fungi Reference number
FE526884 9 isocitrate lyase Glyoxylate cycle enzyme [43, 44]
FE525405 1 malate synthase Glyoxylate cycle enzyme [43, 44]
FE525119 1 citrate synthase Glyoxylate cycle enzyme [43, 44]
FE526004 4 phospholipase B Gene inactivation attenuates virulence in Cryptococcus neoformans and Candida albicans [63, 64]
FE526464 7 subtilisin-like protease Sub3 Sub3 is a dominant protease secreted by Trichophyton rubrum during host infection [65]
FE526467 1, 7, 10 subtilisin-like protease Sub5 Putative Trichophyton rubrum virulence factor [9]
FE526356 7 metalloprotease Mep3 MEP3 is produced by M. canis during guinea pigs infection [66]
FE526553 7 metalloprotease Mep4 Mep4 is a dominant protease secreted by Trichophyton rubrum during host infection [65]
FE526905 9 carboxypeptidase Important for the assimilation of nitrogenous substrates during infection and contributes to the virulence of dermatophytes [50]
FE524895 1 dipeptidyl-peptidase V Dipeptidyl peptidases as potential virulence factors for Microsporum canis [67]
FE526224 2, 7, 8 copper resistance-associated P-type ATPase Cu-ATPase mutants showed reduced virulence in Listeria monocytogenes and Criptococcus neoformans [52, 53, 68]
FE526598 2, 7, 8 Tru MDR2 Gene inactivation attenuates the virulence of Trichophyton rubrum in vitro [40]
FE525063 1 mannosyltransferase Gene inactivation attenuates the virulence of Candida albicans and Aspergillus fumigatus [69, 70]
FE526454 7 urease Gene inactivation reduces the amount of ammonia secreted in vitro and attenuates the virulence of Coccidioides posadasii [32]
FE526352 1, 7 glucosamine-6-phosphate deaminase Gene inactivation attenuates the virulence of Candida albicans in a murine model [71]
FE524999 1 glyceraldehyde-3-phosphate dehydrogenase (GAPDH) GAPDH contributes to the adhesion of Paracoccidioides brasiliensis to host tissues and to the dissemination of infection. [72]
FE527290 10 thioredoxin TrxA Putative Trichophyton mentagrophytes virulence factor [73]
  1. The overexpression of the ESTs from SSH libraries was confirmed by reverse Northern hybridization and/or Northern blot.