Table 6 Target pathway of up-regulated genes in SL1344 vs SB1117 infection groups at 4 days.
Ingenuity Canonical Pathways | Up-regulated | Molecules |
|---|---|---|
Role of Cytokines in Mediating Communication between Immune Cells | 3/57 (5%) | IFNG, IFNA7, IL3 HS6ST1, CYP3A4, 2810007J24RIK, |
LPS/IL-1 Mediated Inhibi tion of RXR f unction | 5/215 (2%) | IL4I1, ABCC4 |
Interferon Signaling | 2/30 (7%) | IFNG, IRF1 |
Retinoic acid Mediated Apoptosis Signaling | 2/44 (5%) | CFLAR, IRF1 |
IL-12 Signaling and Pro duction in m acrophages | 3/134 (2%) | IFNG, IF NA7, IRF1 |
Gα12/13 Signaling | 3/126 (2%) | BTK, F2RL2, MEF2D |
Calcium -induced T Lymphocyte Apoptosis | 2/65 (3%) | MEF2 D, ORAI1 |
Prolactin Signaling | 2/75 (3%) | SOCS3, IRF1 |
VDR/RXR Activation | 2/80 (3%) | IFNG, RUNX2 |
Acute Phase Response Signaling | 3/178 (2%) | SOCS3, TF, IL6R |
Role of NFAT in Regulation of the Immune response | 3/195 (2%) | BTK, MEF2 D, ORAI1 |
Communication between Innate and adaptive Immune Cells | 2/90 (2%) | IFNG, IL3 |
Fc Epsilon RI Signaling | 2/103 (2%) | BTK, IL3 |
Natural Killer Cell Signaling | 2/112 (2%) | KLRK1, HCST |
IL-22 Signaling | 1/28 (4%) | SOCS3 |
IL-15 Production | 1/31 (3%) | IRF1 |
p70S6K Signaling | 2/131 (2%) | BTK, F2RL2 |
IL-9 Signaling | 1/37 (3%) | SOCS3 |
JAK/Stat Signaling | 1/64 (2%) | SOCS3 |