TY - JOUR AU - Monk, Ian R. AU - Casey, Pat G. AU - Hill, Colin AU - Gahan, Cormac GM PY - 2010 DA - 2010/12/13 TI - Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model JO - BMC Microbiology SP - 318 VL - 10 IS - 1 AB - Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts. The interaction of InlA with the host cell ligand E-cadherin efficiently stimulates L. monocytogenes entry into human enterocytes, but has only a limited interaction with murine cells. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-10-318 DO - 10.1186/1471-2180-10-318 ID - Monk2010 ER -