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Table 1 Caco-2 cell genes involved in intracellular junction complex formation that were differentially expressed in the microarray analysis after co-culturing with L. plantarum MB452 (OD600 nm 0.9) for 10 hours.

From: Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

Gene Name Symbol Refseq ID Fold Change Moderated Description of role in relation to tight junctions
occludin OCLN NM_002538 1.39 0.004 tight junction bridging protein
vascular endothelial growth factor A VEGFA NM_001025366 1.39 0.002 cytokine that indirectly regulates tight junction formation and strengthening
actin beta ACTB NM_001101 1.33 0.005 structural constituent of cytoskeleton
cingulin CGN NM_020770 1.29 0.024 tight junction plaque protein associated with occludin
par-6 partitioning defective 6 homolog beta PARD6B NM_032521 1.27 0.009 tight junction plaque protein associated with claudins and involved in cell polarization
actin alpha cardiac muscle 1 ACTC1 NM_005159 1.25 0.015 structural constituent of cytoskeleton
itchy homolog E3 ubiquitin protein ligase ITCH NM_031483 1.25 0.011 ubiquitin-ligase molecule that regulates occludin degradation
junction plakoglobin JUP NM_002230 1.24 0.010 major cytoplasmic protein that forms a complex with cadherins
CNKSR family member 3 CNKSR3 NM_173515 1.24 0.006 tight junction plaque protein associated with JAMs
snail homolog 1 SNAI1 NM_005985 1.24 0.033 intracellular component that indirectly inhibits occuldin production
hepatocyte nuclear factor 4 alpha HNF4A NM_178849 1.24 0.021 transcription regulator that acts on occuldin
zona occludens 1 (tight junction protein 1) ZO-1 NM_003257 1.23 0.013 tight junction plaque protein associated with occludin, JAMs and claudins
zona occludens 2 (tight junction protein 2) ZO-2 NM_004817 1.23 0.054 tight junction plaque protein associated with occludin and claudins that acts as a guanylate kinase and also found in the nucleus
CD2-associated protein CD2AP NM_012120 1.22 0.012 scaffolding molecule that regulates the actin cytoskeleton
vinculin VCL NM_003373 1.22 0.027 cytoskeletal protein
membrane associated guanylate kinase 3 MAGI-3 NM_152900 1.21 0.044 tight junction plaque protein a and guanylate kinase
membrane protein, palmitoylated 5 MPP5 NM_022474 1.20 0.014 tight junction plaque protein associated with claudins and guanylate kinase involved in tight junction organization
cleavage and polyadenylation specific factor 2 CPSF2 NM_017437 -1.22 0.022 transcription regulator that decreases tight junction stability
cyclin-dependent kinase 4 CDK4 NM_000075 -1.30 0.011 transcription regulator that decreases tight junction stability
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BMC Microbiology

ISSN: 1471-2180

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