TY - JOUR AU - Tóth, Judit S. AU - Tombácz, Dóra AU - Takács, Irma F. AU - Boldogkői, Zsolt PY - 2010 DA - 2010/12/06 TI - The effects of viral load on pseudorabies virus gene expression JO - BMC Microbiology SP - 311 VL - 10 IS - 1 AB - Herpesvirus genes are classified into distinct kinetic groups on the basis of their expression dynamics during lytic growth of the virus in cultured cells at a high, typically 10 plaque-forming units/cell multiplicity of infection (MOI). It has been shown that both the host response and the success of a pathogen are dependent on the quantity of particles infecting an organism. This work is a continuation of an earlier study [1], in which we characterized the overall expression of PRV genes following low-MOI infection. In the present study, we have addressed the question of whether viral gene expressions are dependent on the multiplicity of infection by comparing gene expressions under low and high-MOI conditions. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-10-311 DO - 10.1186/1471-2180-10-311 ID - Tóth2010 ER -