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Table 3 Genes of known or predicted function which were down-regulated in response to serum

From: Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum

Gene ID a and COG category Gene Fold ratio Description of gene product Temperature effect b Osmolarity effect c
Information storage and processing      
- translation, ribosomal structure and biogenesis (J)      
LIC12111 (LA1677) rpsR -2.64 30S ribosomal protein S18 - -
LIC12865 (LA0747) rpmC -1.91 50S ribosomal protein L29 - -
LIC12637 (LA1020) rpmE -1.88 50S ribosomal protein L31 - -
LIC10750 (LA3423) rplA -1.82 50S ribosomal protein L1 - -
LIC12862 (LA0750) rplX -1.75 50S ribosomal protein L24 - -
LIC12113 (LA1675) rpsF -1.70 30S ribosomal protein S6 - -
LIC12845 (LA0766) rplQ -1.65 50S ribosomal protein L17 - -
LIC12774 (LA0851) rpmA -1.61 50S ribosomal protein L27 - -
LIC12860 (LA0752) rpsN -1.59 30S ribosomal protein S14 - -
LIC12871 (LA0741) rplW -1.55 50S ribosomal protein L23 - -
LIC10756 (LA3416) rpsG -1.54 30S ribosomal protein S7 - -
LIC10751 (LA3422) rplJ -1.54 50S ribosomal protein L10 - -
LIC12855 (LA0757) rpmD -1.52 50S ribosomal protein L30 - -
- replication, recombination and repair (L)      
LIC20098 (LB122)   -2.80 XerD related protein (integrase family) - d
LIC12112 (LA1676) ssb -1.70 single-stranded DNA-binding protein - -
Cellular process and signaling      
- signal transduction mechanisms (T)      
LIC20012 (LB014)   -2.56 sensor protein of a two-component - -
    response regulator   
LIC11201 (LA2829)   -2.16 receiver component of a two- - -
    component response regulator   
LIC12762 (LA0866)   -1.97 signal transduction protein -
LIC12807 (LA0816)   -1.95 receiver component of a two- d -
    component response regulator   
LIC10344 (LA0395)   -1.88 anti-sigma factor antagonist - -
LIC13344 (LA4189)   -1.86 anti-sigma regulatory factor (Ser/Thr - -
    protein kinase)   
LIC20108 (LB136)   -1.81 anti-sigma factor antagonist -
LIC20025 (LB031)   -1.77 cyclic nucleotide-binding protein - -
LIC11095 (LA2968)   -1.58 adenylate/guanylate cyclase - -
LIC12357 (LA1378)   -1.53 membrane GTPase -
- cell wall/membrane biogenesis (M)      
LIC10271 (LA0312)   -1.66 metallopeptidase, M23/M27 family -
LIC12621 (LA1044)   -1.54 conserved hypothetical protein - -
- posttranslational modification, protein      
turnover, chaperones (O)      
LIC12017 (LA1879) clpA -2.48 endopeptidase Clp - -
LIC12765 (LA0862) tpx -1.90 peroxiredoxin
LIC13442 (LA4299) btuE -1.70 glutathione peroxidase -
LIC20044 (LB058) htpG -1.68 HSP90 - -
LIC20093 (LB117) bcp -1.54 bacterioferritin comigratory protein - -
Metabolism      
- energy production and conversion (C)      
LIC12002 (LA1897) sdhA -1.72 succinate dehydrogenase/fumarate reductase subunit A - -
LIC12476 (LA1222) aceF -1.63 dihydrolipoyllysine-residue acetyl   
    transferase and succinyltransferase - -
LIC12217 (LA1553) petE -1.62 plastocyanin -
LIC12829 (LA0790) gltA -1.53 citrate (Si)-synthase - -
- carbohydrate transport and metabolism      
(G)   -1.82 phosphonomutase -
LIC12331 (LA1416) mgsA -1.72 methylglyoxal synthase - -
LIC12733 (LA0909)   -1.58 adolase -
LIC12233 (LA1532)      
- amino acid transport and metabolism (E)   -2.17 dioxygenase superfamily protein - -
LIC10069 (LA0076) glnK -2.17 nitrogen regulatory protein PII - -
LIC10440 (LA3807) csdB -1.60 selenocysteine lyase - -
LIC20204 (LB267) speD -1.54 adenosylmethionine decarboxylase - -
LIC20239 (LA-SPN3792) gltB -1.53 glutamate synthase (NADH) - -
LIC12694 (LA0956)   -1.52 lactoylglutathione or related lyase - -
LIC10460 (LA3782)      
- nucleotide transport and metabolism (F)   -1.65 purine-nucleoside phosphorylase - -
LIC13399 (LA4248) adk -1.55 adenylate kinase - -
LIC12852 (LA0760)      
- coenzyme transport and metabolism (H) ubiG -1.86 2-polyprenyl-3-methyl-5-   
LIC10737 (LA3436)    hydroxy-6-metoxy-1,4- - -
    benzoquinol methylase   
- lipid transport and metabolism (I) ivd -1.77   - -
LIC10363 (LA0414)    isovaleryl-CoA dehydrogenase   
- inorganic ion transport and metabolism amtB -3.10   - -
(P) kdpA -2.09 ammonia permease -
LIC10441 (LA3806)    potassium-transporting ATPase A   
LIC10990 (LA3112)    chain   
  1. aGene ID is based on predicted ORFs of whole-genome sequence of L. interrogans serovar Copenhageni. Gene ID of corresponding serovar Lai is in parenthesis. ORFs of unknown or poorly characterized function were excluded from this table.
  2. bPrevious microarray data on the effect of overnight 37°C upshift [11] compared to growth at 30°C.
  3. cPrevious microarray data on the effect of osmolarity upshift [13] compared to EMJH medium.
  4. d ↑ represents up-regulation of gene expression and ↓ represents down-regulation of gene expression.