From: Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum
Gene ID a and COG category | Gene | Fold ratio | Description of gene product | Temperature effect b | Osmolarity effect c |
---|---|---|---|---|---|
Information storage and processing | Â | Â | Â | Â | Â |
- translation, ribosomal structure and biogenesis (J) | Â | Â | Â | Â | Â |
LIC12111 (LA1677) | rpsR | -2.64 | 30S ribosomal protein S18 | - | - |
LIC12865 (LA0747) | rpmC | -1.91 | 50S ribosomal protein L29 | - | - |
LIC12637 (LA1020) | rpmE | -1.88 | 50S ribosomal protein L31 | - | - |
LIC10750 (LA3423) | rplA | -1.82 | 50S ribosomal protein L1 | - | - |
LIC12862 (LA0750) | rplX | -1.75 | 50S ribosomal protein L24 | - | - |
LIC12113 (LA1675) | rpsF | -1.70 | 30S ribosomal protein S6 | - | - |
LIC12845 (LA0766) | rplQ | -1.65 | 50S ribosomal protein L17 | - | - |
LIC12774 (LA0851) | rpmA | -1.61 | 50S ribosomal protein L27 | - | - |
LIC12860 (LA0752) | rpsN | -1.59 | 30S ribosomal protein S14 | - | - |
LIC12871 (LA0741) | rplW | -1.55 | 50S ribosomal protein L23 | - | - |
LIC10756 (LA3416) | rpsG | -1.54 | 30S ribosomal protein S7 | - | - |
LIC10751 (LA3422) | rplJ | -1.54 | 50S ribosomal protein L10 | - | - |
LIC12855 (LA0757) | rpmD | -1.52 | 50S ribosomal protein L30 | - | - |
- replication, recombination and repair (L) | Â | Â | Â | Â | Â |
LIC20098 (LB122) |  | -2.80 | XerD related protein (integrase family) | - | ↓d |
LIC12112 (LA1676) | ssb | -1.70 | single-stranded DNA-binding protein | - | - |
Cellular process and signaling | Â | Â | Â | Â | Â |
- signal transduction mechanisms (T) | Â | Â | Â | Â | Â |
LIC20012 (LB014) | Â | -2.56 | sensor protein of a two-component | - | - |
 |  |  | response regulator |  |  |
LIC11201 (LA2829) | Â | -2.16 | receiver component of a two- | - | - |
 |  |  | component response regulator |  |  |
LIC12762 (LA0866) |  | -1.97 | signal transduction protein | - | ↓ |
LIC12807 (LA0816) |  | -1.95 | receiver component of a two- | ↑d | - |
 |  |  | component response regulator |  |  |
LIC10344 (LA0395) | Â | -1.88 | anti-sigma factor antagonist | - | - |
LIC13344 (LA4189) | Â | -1.86 | anti-sigma regulatory factor (Ser/Thr | - | - |
 |  |  | protein kinase) |  |  |
LIC20108 (LB136) |  | -1.81 | anti-sigma factor antagonist | ↓ | - |
LIC20025 (LB031) | Â | -1.77 | cyclic nucleotide-binding protein | - | - |
LIC11095 (LA2968) | Â | -1.58 | adenylate/guanylate cyclase | - | - |
LIC12357 (LA1378) |  | -1.53 | membrane GTPase | - | ↓ |
- cell wall/membrane biogenesis (M) | Â | Â | Â | Â | Â |
LIC10271 (LA0312) |  | -1.66 | metallopeptidase, M23/M27 family | ↑ | - |
LIC12621 (LA1044) | Â | -1.54 | conserved hypothetical protein | - | - |
- posttranslational modification, protein | Â | Â | Â | Â | Â |
turnover, chaperones (O) | Â | Â | Â | Â | Â |
LIC12017 (LA1879) | clpA | -2.48 | endopeptidase Clp | - | - |
LIC12765 (LA0862) | tpx | -1.90 | peroxiredoxin | ↓ | ↓ |
LIC13442 (LA4299) | btuE | -1.70 | glutathione peroxidase | ↑ | - |
LIC20044 (LB058) | htpG | -1.68 | HSP90 | - | - |
LIC20093 (LB117) | bcp | -1.54 | bacterioferritin comigratory protein | - | - |
Metabolism | Â | Â | Â | Â | Â |
- energy production and conversion (C) | Â | Â | Â | Â | Â |
LIC12002 (LA1897) | sdhA | -1.72 | succinate dehydrogenase/fumarate reductase subunit A | - | - |
LIC12476 (LA1222) | aceF | -1.63 | dihydrolipoyllysine-residue acetyl | Â | Â |
 |  |  | transferase and succinyltransferase | - | - |
LIC12217 (LA1553) | petE | -1.62 | plastocyanin | - | ↓ |
LIC12829 (LA0790) | gltA | -1.53 | citrate (Si)-synthase | - | - |
- carbohydrate transport and metabolism | Â | Â | Â | Â | Â |
(G) |  | -1.82 | phosphonomutase | - | ↓ |
LIC12331 (LA1416) | mgsA | -1.72 | methylglyoxal synthase | - | - |
LIC12733 (LA0909) |  | -1.58 | adolase | - | ↓ |
LIC12233 (LA1532) | Â | Â | Â | Â | Â |
- amino acid transport and metabolism (E) | Â | -2.17 | dioxygenase superfamily protein | - | - |
LIC10069 (LA0076) | glnK | -2.17 | nitrogen regulatory protein PII | - | - |
LIC10440 (LA3807) | csdB | -1.60 | selenocysteine lyase | - | - |
LIC20204 (LB267) | speD | -1.54 | adenosylmethionine decarboxylase | - | - |
LIC20239 (LA-SPN3792) | gltB | -1.53 | glutamate synthase (NADH) | - | - |
LIC12694 (LA0956) | Â | -1.52 | lactoylglutathione or related lyase | - | - |
LIC10460 (LA3782) | Â | Â | Â | Â | Â |
- nucleotide transport and metabolism (F) | Â | -1.65 | purine-nucleoside phosphorylase | - | - |
LIC13399 (LA4248) | adk | -1.55 | adenylate kinase | - | - |
LIC12852 (LA0760) | Â | Â | Â | Â | Â |
- coenzyme transport and metabolism (H) | ubiG | -1.86 | 2-polyprenyl-3-methyl-5- | Â | Â |
LIC10737 (LA3436) | Â | Â | hydroxy-6-metoxy-1,4- | - | - |
 |  |  | benzoquinol methylase |  |  |
- lipid transport and metabolism (I) | ivd | -1.77 | Â | - | - |
LIC10363 (LA0414) | Â | Â | isovaleryl-CoA dehydrogenase | Â | Â |
- inorganic ion transport and metabolism | amtB | -3.10 | Â | - | - |
(P) | kdpA | -2.09 | ammonia permease | ↑ | - |
LIC10441 (LA3806) | Â | Â | potassium-transporting ATPase A | Â | Â |
LIC10990 (LA3112) | Â | Â | chain | Â | Â |