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Table 1 Ranking of serotype specific macrolide nonsusceptibility among IPD isolates in Germany from 1992 to 2008 (n, overall = 11,807; n, adults = 8,834; n, children = 2,973)

From: Macrolide susceptibility and serotype specific macrolide resistance of invasive isolates of Streptococcus pneumoniae in Germany from 1992 to 2008

  children adults overall
Sero
type
I% R% S% total
(n)
I% R% S% total
(n)
I% R% S% total
(n)
total
(%)
14 0.0 67.4 32.6 663 0.2 71.0 28.8 883 0.1 69.5 30.4 1546 16.4
45 - - - - 0.0 33.3 66.7 3 0.0 33.3 66.7 3 0.0
19B 0.0 0.0 100.0 1 0.0 50.0 50.0 2 0.0 33.3 66.7 3 0.0
rough 0.0 25.0 75.0 8 0.0 40.0 60.0 10 0.0 33.3 66.7 18 0.2
6B 0.0 29.3 70.7 215 0.4 36.2 63.4 232 0.2 32.9 66.9 447 4.8
15A 4.8 28.6 66.7 21 0.0 33.3 66.7 27 2.1 31.3 66.7 48 0.5
19F 0.0 24.5 75.5 212 0.4 27.5 72.0 236 0.2 26.1 73.7 448 4.8
19A 0.0 24.4 75.6 90 0.9 26.0 73.2 231 0.6 25.5 73.8 321 3.4
10B - - - - 0.0 20.0 80.0 10 0.0 20.0 80.0 10 0.1
19C 0.0 0.0 100.0 2 0.0 33.3 66.7 3 0.0 20.0 80.0 5 0.1
15B 0.0 23.1 76.9 26 0.0 17.5 82.5 57 0.0 19.3 80.7 83 0.9
23F 0.5 20.4 79.1 201 0.6 18.3 81.2 356 0.5 19.0 80.4 557 5.9
9V 0.9 13.2 85.8 106 1.3 20.1 78.5 298 1.2 18.3 80.4 404 4.3
NT 0.0 10.0 90.0 10 0.0 20.7 79.3 29 0.0 17.9 82.1 39 0.4
11F - - - - 0.0 16.7 83.3 6 0.0 16.7 83.3 6 0.1
15C 0.0 15.4 84.6 26 0.0 14.8 85.2 27 0.0 15.1 84.9 53 0.6
9A 0.0 9.5 90.5 21 0.0 19.2 80.8 26 0.0 14.9 85.1 47 0.5
33B 0.0 0.0 100.0 3 0.0 25.0 75.0 4 0.0 14.3 85.7 7 0.1
33A 0.0 11.1 88.9 9 0.0 14.3 85.7 21 0.0 13.3 86.7 30 0.3
33F 0.0 0.0 100.0 17 0.0 17.6 82.4 51 0.0 13.2 86.8 68 0.7
12B 0.0 0.0 100.0 3 0.0 20.0 80.0 5 0.0 12.5 87.5 8 0.1
6A 0.0 5.5 94.5 128 0.4 9.7 89.9 277 0.2 8.4 91.4 405 4.3
28A 0.0 0.0 100.0 4 0.0 12.5 87.5 8 0.0 8.3 91.7 12 0.1
35F 0.0 10.0 90.0 10 0.0 7.8 92.2 64 0.0 8.1 91.9 74 0.8
24F 0.0 6.8 93.2 44 0.0 6.9 93.1 72 0.0 6.9 93.1 116 1.2
13 0.0 0.0 100.0 3 0.0 8.3 91.7 12 0.0 6.7 93.3 15 0.2
16F 0.0 0.0 100.0 7 3.7 7.4 88.9 27 2.9 5.9 91.2 34 0.4
17F 0.0 12.5 87.5 8 0.0 3.2 96.8 31 0.0 5.1 94.9 39 0.4
38 0.0 0.0 100.0 23 0.0 7.9 92.1 38 0.0 4.9 95.1 61 0.6
34 0.0 16.7 83.3 6 0.0 0.0 100.0 15 0.0 4.8 95.2 21 0.2
9N 0.0 0.0 100.0 25 0.0 5.5 94.5 145 0.0 4.7 95.3 170 1.8
11A 0.0 0.0 100.0 15 0.0 5.2 94.8 135 0.0 4.7 95.3 150 1.6
18A 0.0 0.0 100.0 10 0.0 8.3 91.7 12 0.0 4.5 95.5 22 0.2
1 0.4 5.2 94.4 232 0.2 3.5 96.3 458 0.3 4.1 95.7 690 7.3
7F 0.0 3.9 96.1 203 0.4 3.7 95.9 515 0.3 3.8 96.0 718 7.6
5 0.0 0.0 100.0 19 0.0 5.4 94.6 37 0.0 3.6 96.4 56 0.6
10A 0.0 4.0 96.0 50 0.0 2.5 97.5 122 0.0 2.9 97.1 172 1.8
4 0.0 2.9 97.1 102 0.0 2.2 97.8 409 0.0 2.3 97.7 511 5.4
20 0.0 0.0 100.0 5 0.0 2.6 97.4 38 0.0 2.3 97.7 43 0.5
18C 0.6 1.7 97.8 181 0.0 2.8 97.2 145 0.3 2.1 97.5 326 3.5
3 0.0 3.1 96.9 96 0.2 1.8 98.0 663 0.1 2.0 97.9 759 8.1
12F 0.0 0.0 100.0 16 0.0 1.9 98.1 105 0.0 1.7 98.3 121 1.3
8 0.0 0.0 100.0 18 0.5 1.6 97.9 190 0.5 1.4 98.1 208 2.2
23A 0.0 0.0 100.0 14 0.0 1.4 98.6 74 0.0 1.1 98.9 88 0.9
22F 0.0 0.0 100.0 20 0.5 0.5 98.9 186 0.5 0.5 99.0 206 2.2
2 0.0 0.0 100.0 1 0.0 0.0 100.0 11 0.0 0.0 100.0 12 0.1
31 0.0 0.0 100.0 1 0.0 0.0 100.0 25 0.0 0.0 100.0 26 0.3
12A 0.0 0.0 100.0 3 0.0 0.0 100.0 9 0.0 0.0 100.0 12 0.1
18F 0.0 0.0 100.0 5 0.0 0.0 100.0 10 0.0 0.0 100.0 15 0.2
23B 0.0 0.0 100.0 6 0.0 0.0 100.0 11 0.0 0.0 100.0 17 0.2
35B 0.0 0.0 100.0 3 0.0 0.0 100.0 8 0.0 0.0 100.0 11 0.1
9L 0.0 0.0 100.0 5 0.0 0.0 100.0 12 0.0 0.0 100.0 17 0.2
Others* 0.0 0.0 100.0 31 0.0 0.0 100.0 62 0.0 0.0 100.0 93 1.0
not serotyped 0.0 4.4 95.6 45 0.2 0.0 99.8 2360 0.2 0.1 99.8 2405 -
total (%) 0.2 23.8 76.1 - 0.3 13.4 86.3 - 0.2 16.0 83.7 - 100.0
total (n) 5 707 2261 2973 24 1184 7626 8834 29 1891 9887 11807 9402
  1. I%, intermediate isolates in percent; R%, resistant isolates in percent; S%, susceptible isolates in percent; n, number of isolates tested.
  2. Total (n) represents the number of isolates collected from both children and adults. Total (%) represents the serotype distribution in percent in relation to the number of 9402 IPD isolates serotyped.
  3. Others* includes the serotypes (number of isolates, overall): 15F (9), 18B (9), 7C (8), 10F (6), 11B (6), 35A (6), 29 (5), 21 (4), 24A (4), 28F (4), 35C (4), 37 (4), 22A (3), 36 (3), 7A (3), 24B (2), 25F (2), 39 (2), 48 (2), 7B (2), 17A (1), 18 (1), 19 (1), 35 (1), 9 (1).