Table 1 Ranking of serotype specific macrolide nonsusceptibility among IPD isolates in Germany from 1992 to 2008 (n, overall = 11,807; n, adults = 8,834; n, children = 2,973)
children | adults | overall | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sero type | I% | R% | S% | total (n) | I% | R% | S% | total (n) | I% | R% | S% | total † (n) | total ‡ (%) |
14 | 0.0 | 67.4 | 32.6 | 663 | 0.2 | 71.0 | 28.8 | 883 | 0.1 | 69.5 | 30.4 | 1546 | 16.4 |
45 | - | - | - | - | 0.0 | 33.3 | 66.7 | 3 | 0.0 | 33.3 | 66.7 | 3 | 0.0 |
19B | 0.0 | 0.0 | 100.0 | 1 | 0.0 | 50.0 | 50.0 | 2 | 0.0 | 33.3 | 66.7 | 3 | 0.0 |
rough | 0.0 | 25.0 | 75.0 | 8 | 0.0 | 40.0 | 60.0 | 10 | 0.0 | 33.3 | 66.7 | 18 | 0.2 |
6B | 0.0 | 29.3 | 70.7 | 215 | 0.4 | 36.2 | 63.4 | 232 | 0.2 | 32.9 | 66.9 | 447 | 4.8 |
15A | 4.8 | 28.6 | 66.7 | 21 | 0.0 | 33.3 | 66.7 | 27 | 2.1 | 31.3 | 66.7 | 48 | 0.5 |
19F | 0.0 | 24.5 | 75.5 | 212 | 0.4 | 27.5 | 72.0 | 236 | 0.2 | 26.1 | 73.7 | 448 | 4.8 |
19A | 0.0 | 24.4 | 75.6 | 90 | 0.9 | 26.0 | 73.2 | 231 | 0.6 | 25.5 | 73.8 | 321 | 3.4 |
10B | - | - | - | - | 0.0 | 20.0 | 80.0 | 10 | 0.0 | 20.0 | 80.0 | 10 | 0.1 |
19C | 0.0 | 0.0 | 100.0 | 2 | 0.0 | 33.3 | 66.7 | 3 | 0.0 | 20.0 | 80.0 | 5 | 0.1 |
15B | 0.0 | 23.1 | 76.9 | 26 | 0.0 | 17.5 | 82.5 | 57 | 0.0 | 19.3 | 80.7 | 83 | 0.9 |
23F | 0.5 | 20.4 | 79.1 | 201 | 0.6 | 18.3 | 81.2 | 356 | 0.5 | 19.0 | 80.4 | 557 | 5.9 |
9V | 0.9 | 13.2 | 85.8 | 106 | 1.3 | 20.1 | 78.5 | 298 | 1.2 | 18.3 | 80.4 | 404 | 4.3 |
NT | 0.0 | 10.0 | 90.0 | 10 | 0.0 | 20.7 | 79.3 | 29 | 0.0 | 17.9 | 82.1 | 39 | 0.4 |
11F | - | - | - | - | 0.0 | 16.7 | 83.3 | 6 | 0.0 | 16.7 | 83.3 | 6 | 0.1 |
15C | 0.0 | 15.4 | 84.6 | 26 | 0.0 | 14.8 | 85.2 | 27 | 0.0 | 15.1 | 84.9 | 53 | 0.6 |
9A | 0.0 | 9.5 | 90.5 | 21 | 0.0 | 19.2 | 80.8 | 26 | 0.0 | 14.9 | 85.1 | 47 | 0.5 |
33B | 0.0 | 0.0 | 100.0 | 3 | 0.0 | 25.0 | 75.0 | 4 | 0.0 | 14.3 | 85.7 | 7 | 0.1 |
33A | 0.0 | 11.1 | 88.9 | 9 | 0.0 | 14.3 | 85.7 | 21 | 0.0 | 13.3 | 86.7 | 30 | 0.3 |
33F | 0.0 | 0.0 | 100.0 | 17 | 0.0 | 17.6 | 82.4 | 51 | 0.0 | 13.2 | 86.8 | 68 | 0.7 |
12B | 0.0 | 0.0 | 100.0 | 3 | 0.0 | 20.0 | 80.0 | 5 | 0.0 | 12.5 | 87.5 | 8 | 0.1 |
6A | 0.0 | 5.5 | 94.5 | 128 | 0.4 | 9.7 | 89.9 | 277 | 0.2 | 8.4 | 91.4 | 405 | 4.3 |
28A | 0.0 | 0.0 | 100.0 | 4 | 0.0 | 12.5 | 87.5 | 8 | 0.0 | 8.3 | 91.7 | 12 | 0.1 |
35F | 0.0 | 10.0 | 90.0 | 10 | 0.0 | 7.8 | 92.2 | 64 | 0.0 | 8.1 | 91.9 | 74 | 0.8 |
24F | 0.0 | 6.8 | 93.2 | 44 | 0.0 | 6.9 | 93.1 | 72 | 0.0 | 6.9 | 93.1 | 116 | 1.2 |
13 | 0.0 | 0.0 | 100.0 | 3 | 0.0 | 8.3 | 91.7 | 12 | 0.0 | 6.7 | 93.3 | 15 | 0.2 |
16F | 0.0 | 0.0 | 100.0 | 7 | 3.7 | 7.4 | 88.9 | 27 | 2.9 | 5.9 | 91.2 | 34 | 0.4 |
17F | 0.0 | 12.5 | 87.5 | 8 | 0.0 | 3.2 | 96.8 | 31 | 0.0 | 5.1 | 94.9 | 39 | 0.4 |
38 | 0.0 | 0.0 | 100.0 | 23 | 0.0 | 7.9 | 92.1 | 38 | 0.0 | 4.9 | 95.1 | 61 | 0.6 |
34 | 0.0 | 16.7 | 83.3 | 6 | 0.0 | 0.0 | 100.0 | 15 | 0.0 | 4.8 | 95.2 | 21 | 0.2 |
9N | 0.0 | 0.0 | 100.0 | 25 | 0.0 | 5.5 | 94.5 | 145 | 0.0 | 4.7 | 95.3 | 170 | 1.8 |
11A | 0.0 | 0.0 | 100.0 | 15 | 0.0 | 5.2 | 94.8 | 135 | 0.0 | 4.7 | 95.3 | 150 | 1.6 |
18A | 0.0 | 0.0 | 100.0 | 10 | 0.0 | 8.3 | 91.7 | 12 | 0.0 | 4.5 | 95.5 | 22 | 0.2 |
1 | 0.4 | 5.2 | 94.4 | 232 | 0.2 | 3.5 | 96.3 | 458 | 0.3 | 4.1 | 95.7 | 690 | 7.3 |
7F | 0.0 | 3.9 | 96.1 | 203 | 0.4 | 3.7 | 95.9 | 515 | 0.3 | 3.8 | 96.0 | 718 | 7.6 |
5 | 0.0 | 0.0 | 100.0 | 19 | 0.0 | 5.4 | 94.6 | 37 | 0.0 | 3.6 | 96.4 | 56 | 0.6 |
10A | 0.0 | 4.0 | 96.0 | 50 | 0.0 | 2.5 | 97.5 | 122 | 0.0 | 2.9 | 97.1 | 172 | 1.8 |
4 | 0.0 | 2.9 | 97.1 | 102 | 0.0 | 2.2 | 97.8 | 409 | 0.0 | 2.3 | 97.7 | 511 | 5.4 |
20 | 0.0 | 0.0 | 100.0 | 5 | 0.0 | 2.6 | 97.4 | 38 | 0.0 | 2.3 | 97.7 | 43 | 0.5 |
18C | 0.6 | 1.7 | 97.8 | 181 | 0.0 | 2.8 | 97.2 | 145 | 0.3 | 2.1 | 97.5 | 326 | 3.5 |
3 | 0.0 | 3.1 | 96.9 | 96 | 0.2 | 1.8 | 98.0 | 663 | 0.1 | 2.0 | 97.9 | 759 | 8.1 |
12F | 0.0 | 0.0 | 100.0 | 16 | 0.0 | 1.9 | 98.1 | 105 | 0.0 | 1.7 | 98.3 | 121 | 1.3 |
8 | 0.0 | 0.0 | 100.0 | 18 | 0.5 | 1.6 | 97.9 | 190 | 0.5 | 1.4 | 98.1 | 208 | 2.2 |
23A | 0.0 | 0.0 | 100.0 | 14 | 0.0 | 1.4 | 98.6 | 74 | 0.0 | 1.1 | 98.9 | 88 | 0.9 |
22F | 0.0 | 0.0 | 100.0 | 20 | 0.5 | 0.5 | 98.9 | 186 | 0.5 | 0.5 | 99.0 | 206 | 2.2 |
2 | 0.0 | 0.0 | 100.0 | 1 | 0.0 | 0.0 | 100.0 | 11 | 0.0 | 0.0 | 100.0 | 12 | 0.1 |
31 | 0.0 | 0.0 | 100.0 | 1 | 0.0 | 0.0 | 100.0 | 25 | 0.0 | 0.0 | 100.0 | 26 | 0.3 |
12A | 0.0 | 0.0 | 100.0 | 3 | 0.0 | 0.0 | 100.0 | 9 | 0.0 | 0.0 | 100.0 | 12 | 0.1 |
18F | 0.0 | 0.0 | 100.0 | 5 | 0.0 | 0.0 | 100.0 | 10 | 0.0 | 0.0 | 100.0 | 15 | 0.2 |
23B | 0.0 | 0.0 | 100.0 | 6 | 0.0 | 0.0 | 100.0 | 11 | 0.0 | 0.0 | 100.0 | 17 | 0.2 |
35B | 0.0 | 0.0 | 100.0 | 3 | 0.0 | 0.0 | 100.0 | 8 | 0.0 | 0.0 | 100.0 | 11 | 0.1 |
9L | 0.0 | 0.0 | 100.0 | 5 | 0.0 | 0.0 | 100.0 | 12 | 0.0 | 0.0 | 100.0 | 17 | 0.2 |
Others* | 0.0 | 0.0 | 100.0 | 31 | 0.0 | 0.0 | 100.0 | 62 | 0.0 | 0.0 | 100.0 | 93 | 1.0 |
not serotyped | 0.0 | 4.4 | 95.6 | 45 | 0.2 | 0.0 | 99.8 | 2360 | 0.2 | 0.1 | 99.8 | 2405 | - |
total (%) | 0.2 | 23.8 | 76.1 | - | 0.3 | 13.4 | 86.3 | - | 0.2 | 16.0 | 83.7 | - | 100.0 |
total (n) | 5 | 707 | 2261 | 2973 | 24 | 1184 | 7626 | 8834 | 29 | 1891 | 9887 | 11807 | 9402 |