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Table 3 Relative differences in cytokine amounts between L. plantarum WCFS1 wild-type and deletion mutants.

From: Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells

   IL-10c IL-12 IL-10/IL-12
Mutant
comparisona
Growth
phaseb
value p-value adj. p-
value
value p-value adj. p-
value
value p-value adj. p-
value
lp_1953 log 0.097 0.461 0.830 -0.041 0.775 0.825 0.138 0.161 0.803
  stat 0.253 0.057 0.228 -0.043 0.761 0.825 0.296 0.003 0.024 *
pts19ADCBR log 0.164 0.216 0.647 0.106 0.458 0.825 0.058 0.556 0.923
  stat 0.396 0.004 0.031 * -0.131 0.371 0.825 0.529 0.000 0.000 ***
plnEFI log 0.287 0.031 0.176 0.032 0.825 0.825 0.255 0.010 0.071
  stat 0.344 0.010 0.071 0.174 0.225 0.825 0.170 0.084 0.507
plnG log 0.280 0.035 0.176 -0.070 0.625 0.825 0.350 0.000 0.005 **
  stat -0.028 0.830 0.830 -0.146 0.307 0.825 0.118 0.230 0.921
lamA lamR log 0.511 0.000 0.001 *** 0.199 0.165 0.825 0.312 0.002 0.016 *
  stat 1.331 0.000 0.000 *** 1.321 0.000 0.000 *** 0.009 0.923 0.923
  1. aL. plantarum WCFS1 deletion mutant measured in the PBMC assay.
  2. bPhase of growth from which L. plantarum cells were harvested (log = exponential phase; stat = stationary phase).
  3. cThe value is the average difference in 2Log cytokine amounts induced by wild-type L. plantarum and mutant cells harvested in the same phase of growth (log or stat). A positive value indicates an increase in IL-10 levels produced by PBMCs in response to mutant L. plantarum compared to the wild-type cells. Calculations of t-test p-values and adjusted (adj.) p-values are described in the text (Materials and Methods). * (0.01 < p < 0.05); ** (0.002 < p < 0.01); *** (p < 0.002) for the adj. p-values.