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Table 1 Genes expressed differentially in strain 1457ΔlytSR compared to the wild-type strain

From: Impact of the Staphylococcus epidermidis LytSR two-component regulatory system on murein hydrolase activity, pyruvate utilization and global transcriptional profile

ORF Gene name Description or predicted function Expression ratio (Mutant/WT)
Amino acid biosynthesis
SERP0034 metE 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase 2.096
SERP0108 gltB glutamate synthase large subunit 2.405
SERP0548 argH argininosuccinate lyase 5.03
SERP1103 aroK shikimate kinase 2.274
SERP1668 ilvC ketol-acid reductoisomerase 2.087
SERP1669 leuA 2-isopropylmalate synthase 2.344
SERP1670 leuB 3-isopropylmalate dehydrogenase 2.229
SERP1671 leuC 3-isopropylmalate dehydratase small subunit 11.45
SERP2301 hisF imidazoleglycerol phosphate synthase, cyclase subunit 5.429
Amino acid transport
SERP0392   di-tripeptide transporter, putative 3.362
SERP0571 oppC oligopeptide transport system permease protein OppC 12.38
SERP0950   peptide ABC transporter, ATP-binding protein, putative 3.383
SERP1440 putP proline permease 2.124
SERP1935 gltS sodium:glutamate symporter 3.267
Inorganic ion transport and metabolism
SERP0284   Na+/H+ antiporter, MnhD component, putative 3.294
SERP0287   Na+/H+ antiporter, MnhG component, putative 2.576
SERP0660   cobalt transport family protein 2.718
SERP1777   iron compound ABC transporter, iron 2.383
SERP1859 modC molybdenum transport ATP-binding protein 3.294
SERP2428 arsA arsenical pump-driving ATPase 3.274
Protein synthesis
SERP0721 pheS Phe-tRNA synthetase alpha chain 2.036
SERP1809 infA translation initiation factor IF-1 0.5
SERP1812 rplO ribosomal protein L15 0.482
SERP1813 rpmD ribosomal protein L30 0.333
SERP1814 rpsE 30 S ribosomal protein S5 0.37
SERP1815 rplR 50 S ribosomal protein L18 0.323
SERP1816 rplF 50 S ribosomal protein L6 0.332
SERP1817 rpsH 30 S ribosomal protein S8 0.357
SERP1818 rpsN-2 30 S ribosomal protein S14 0.306
SERP1819 rplE 50 S ribosomal protein L5 0.324
SERP1821 rplN 50 S ribosomal protein L14 0.346
SERP1820 rplX 50 S ribosomal protein L24 0.356
SERP1822 rpsQ 30 S ribosomal protein S17 0.344
SERP1823 rpmC 50 S ribosomal protein L29 0.332
SERP1824 rplP 50 S ribosomal protein L16 0.438
SERP1825 rpsC 30 S ribosomal protein S3 0.345
SERP1826 rplV 50 S ribosomal protein L22 0.374
SERP1827 rpsS 30 S ribosomal protein S19 0.385
SERP1828 rplB 50 S ribosomal protein L2 0.421
SERP1829 rplW 50 S ribosomal protein L23 0.424
Nucleotide metabolism
SERP0070 guaA bifunctional GMP synthase/glutamine amidotransferase protein 2.546
SERP0651 purC phosphoribosylaminoimidazole-succinocarboxamide synthase 2.036
SERP0654 purL phosphoribosylformylglycinamidine synthetase 2.341
SERP0655 purF phosphoribosylpyrophosphate amidotransferase 2.164
SERP0656 purM phosphoribosylformylglycinamidine cyclo-ligase 2.369
SERP0657 purN IMP cyclohydrolase 2.111
SERP1003 thyA-1 thymidylate synthase 2.014
SERP1810 adk adenylate kinase 0.444
Energy metabolism
SE0102-12228   carbamate kinase, putative 0.259
SE0104-12228   transcription regulator Crp/Fnr family protein 0.343
SE0106-12228 arcA arginine deiminase 0.301
SERP0672 cydA cytochrome d ubiquinol oxidase subunit II-like protein 13.85
SERP1985 narJ nitrate reductase delta chain 0.441
SERP1986 narH nitrate reductase beta chain 0.327
SERP1987 narG nitrate reductase alpha chain 0.324
SERP1990 nirB nitrite reductase nitrite reductase 0.354
SERP2168 mqo-2 malate:quinone oxidoreductase 0.317
SERP2169   hypothetical protein 0.0165
SERP2261 manA-2 mannose-6-phosphate isomerase 0.479
SERP2312 mqo-3 malate:quinone oxidoreductase 0.451
SERP2352 arcC putative carbamate kinase 0.427
DNA replication, recombination and repair
SERP0558   ISSep1-like transposase 4.66
SERP0599   site-specific recombinase, resolvase family 2.352
SERP0892   IS1272, transposase 2.774
SERP0909 lexA SOS regulatory LexA protein 2.227
SERP1023   DNA replication protein DnaD, putative 2.049
SERP2474 hsdR type I restriction-modification system, R subunit 46.79
Transcriptional regulator
SERP0635   transcriptional regulator, MarR family 3.216
SERP1879   transcriptional regulator, AraC family 21.2
  1. * The entire list of differentially expressed genes can be found on the National Center for Biotechnology Information Gene Expression Omnibus (GEO, available at http://www.ncbi.nlm.nih.gov/geo/ and is accessible through GEO Series accession number GSE20652