Figure 5

Iron dependent metabolic programming in cattle and sheep MAP: Under iron-replete conditions, there is upregulation of ribosomal proteins, bacterioferritin, mycobacterial heme, utilization and degrader proteins in cattle strain alone. Under iron limiting conditions, siderophore synthesis and transport genes are upregulated in both cattleI and sheep MAP strains. However, under iron limitation there is downregulation of aconitase, succinate dehydrogenases and superoxide dismutase in cattle MAP strain alone. This suggests an iron-sparing response exclusively in cattle but not sheep strain.