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Table 2 Attenuation of P. aeruginosa virulence factors by pre-elafin/trappin-2, elafin and cementoin

From: Structural and antimicrobial properties of human pre-elafin/trappin-2 and derived peptides against Pseudomonas aeruginosa

Peptide [μM] %1 Pyoverdine % Las B % Alginate % Biofilm
Pre-elafin/trappin-2 4 71 ± 2 83 ± 2 76 ± 2 70 ± 2
  8 59 ± 2 75 ± 2 72 ± 2 57 ± 4
Elafin 4 82 ± 2 87 ± 4 79 ± 3 86 ± 2
  8 69 ± 1 73 ± 5 77 ± 2 69 ± 2
Cementoin 4 96 ± 2 96 ± 4 95 ± 1 94 ± 2
  8 91 ± 1 88 ± 4 87 ± 2 87 ± 2
Azithromycin 4 69 ± 2 85 ± 4 80 ± 3 62 ± 4
  8 55 ± 2 76 ± 2 75 ± 3 44 ± 5
  1. 1The results are expressed as a percentage ± SD relative to P. aeruginosa cultures grown in the absence of peptides, which were set at 100%. For the assays of pyoverdine and lasB the values represent the mean of 3 experiments performed in duplicata. For the assays of alginate and biofilm formation the values represent the mean of 3 experiments.