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Table 2 Attenuation of P. aeruginosa virulence factors by pre-elafin/trappin-2, elafin and cementoin

From: Structural and antimicrobial properties of human pre-elafin/trappin-2 and derived peptides against Pseudomonas aeruginosa

Peptide

[μM]

%1 Pyoverdine

% Las B

% Alginate

% Biofilm

Pre-elafin/trappin-2

4

71 ± 2

83 ± 2

76 ± 2

70 ± 2

 

8

59 ± 2

75 ± 2

72 ± 2

57 ± 4

Elafin

4

82 ± 2

87 ± 4

79 ± 3

86 ± 2

 

8

69 ± 1

73 ± 5

77 ± 2

69 ± 2

Cementoin

4

96 ± 2

96 ± 4

95 ± 1

94 ± 2

 

8

91 ± 1

88 ± 4

87 ± 2

87 ± 2

Azithromycin

4

69 ± 2

85 ± 4

80 ± 3

62 ± 4

 

8

55 ± 2

76 ± 2

75 ± 3

44 ± 5

  1. 1The results are expressed as a percentage ± SD relative to P. aeruginosa cultures grown in the absence of peptides, which were set at 100%. For the assays of pyoverdine and lasB the values represent the mean of 3 experiments performed in duplicata. For the assays of alginate and biofilm formation the values represent the mean of 3 experiments.