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Table 1 Differentially expressed host genes modulated by C. burnetii protein synthesis.

From: Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection

Cellular Function

Gene Symbol

Cellular location

Predicted Function(s)

-CAM1

+CAM2

FD3

 

CTSB

Cytoplasm

peptidase

3.102

6.565

↑3.463

Apoptosis

CTSL1

Cytoplasm

peptidase

3.173

6.914

↑3.741

 

BCL3

Nucleus

transcription regulator

3.103

5.673

↑2.57

 

C11ORF82

Cytoplasm

other

-1.849

-4.912

↓3.062

Cell proliferation

SOX11

Nucleus

transcription regulator

3.127

-2.915

↓6.042

 

HELLS

Nucleus

enzyme

-1.551

-4.653

↓3.101

 

PGR

Nucleus

ligand-depend. nuclear recept.

-1.539

-6.853

↓5.313

 

ITK

Cytoplasm

kinase

2.752

-2.46

↓5.212

Cell signaling

DUSP9

Nucleus

phosphatase

-2.04

-4.388

↓2.348

 

SKP2

Nucleus

other

1.581

-2.627

↓4.208

 

MTSS1

Cytoplasm

other

4.389

6.986

↑2.597

Cytoskeleton

ANLN

Cytoplasm

other

-1.943

-4.679

↓2.735

 

SMTN

Extracell. space

other

-3.319

4.006

↑7.325

 

PLEKHO1

Plasma memb.

other

2.162

5.396

↑3.234

 

SPP1

Extracell. space

cytokine

3.351

6.733

↑3.382

Immune response

CCL2

Extracell. space

cytokine

5.053

7.451

↑2.398

 

CXCL1

Extracell. space

cytokine

5.221

7.275

↑2.054

 

IL8

Extracell. space

cytokine

7.839

9.985

↑2.146

 

FABP4

Cytoplasm

transporter

2.351

4.506

↑2.155

Lipid metabolism

APOE

Extracell. space

transporter

2.591

4.958

↑2.367

 

PLIN2

Plasma memb.

other

3.725

5.772

↑2.047

 

RAB20

Cytoplasm

enzyme

2.489

4.925

↑2.436

 

FAM177B

Unknown

other

5.064

7.125

↑2.061

 

SELM

Cytoplasm

other

-2.23

2.531

↑4.761

 

PSMA8

Cytoplasm

peptidase

-2.494

3.212

↑5.706

 

MSC

Cytoplasm

transcription regulator

3.17

5.49

↑2.32

 

MRPL44

Cytoplasm

enzyme

2.775

-1.356

↓4.131

Miscelleaneous

CHMP5

Cytoplasm

other

1.525

-2.189

↓3.714

 

RORA

Nucleus

ligand-depend. nuclear recept.

-6.756

7.147

↑13.903

 

ZFP36L1

Nucleus

transcription regulator

3.815

6.842

↑3.027

 

ZNF573

Nucleus

other

1.412

-3.322

↓4.734

 

SLC22A6

Plasma memb.

transporter

2.097

-2.146

↓4.243

 

CDH2

Plasma memb.

other

-1.626

-3.634

↓2.007

 

KIAA1279

Unknown

enzyme

7.811

12.888

↑5.077

 

SPATA6

Unknown

other

-2.473

19.906

↑22.379

 

PSD4

Unknown

other

2.197

-2.149

↓4.346

  1. 1Fold change of expressed THP-1 genes in response to C. burnetii infection under mock treated condition.
  2. 2Fold change of expressed THP-1 genes in response to C. burnetii infection under CAM treated condition.
  3. 3Fold change difference increase (↑) or decrease (↓) between 1 and 2.