|
Cellular Function
|
Gene Symbol
|
Cellular location
|
Predicted Function(s)
|
-CAM1
|
+CAM2
|
FD3
|
|---|
| |
CTSB
|
Cytoplasm
|
peptidase
|
3.102
|
6.565
|
↑3.463
|
|
Apoptosis
|
CTSL1
|
Cytoplasm
|
peptidase
|
3.173
|
6.914
|
↑3.741
|
| |
BCL3
|
Nucleus
|
transcription regulator
|
3.103
|
5.673
|
↑2.57
|
| |
C11ORF82
|
Cytoplasm
|
other
|
-1.849
|
-4.912
|
↓3.062
|
|
Cell proliferation
|
SOX11
|
Nucleus
|
transcription regulator
|
3.127
|
-2.915
|
↓6.042
|
| |
HELLS
|
Nucleus
|
enzyme
|
-1.551
|
-4.653
|
↓3.101
|
| |
PGR
|
Nucleus
|
ligand-depend. nuclear recept.
|
-1.539
|
-6.853
|
↓5.313
|
| |
ITK
|
Cytoplasm
|
kinase
|
2.752
|
-2.46
|
↓5.212
|
|
Cell signaling
|
DUSP9
|
Nucleus
|
phosphatase
|
-2.04
|
-4.388
|
↓2.348
|
| |
SKP2
|
Nucleus
|
other
|
1.581
|
-2.627
|
↓4.208
|
| |
MTSS1
|
Cytoplasm
|
other
|
4.389
|
6.986
|
↑2.597
|
|
Cytoskeleton
|
ANLN
|
Cytoplasm
|
other
|
-1.943
|
-4.679
|
↓2.735
|
| |
SMTN
|
Extracell. space
|
other
|
-3.319
|
4.006
|
↑7.325
|
| |
PLEKHO1
|
Plasma memb.
|
other
|
2.162
|
5.396
|
↑3.234
|
| |
SPP1
|
Extracell. space
|
cytokine
|
3.351
|
6.733
|
↑3.382
|
|
Immune response
|
CCL2
|
Extracell. space
|
cytokine
|
5.053
|
7.451
|
↑2.398
|
| |
CXCL1
|
Extracell. space
|
cytokine
|
5.221
|
7.275
|
↑2.054
|
| |
IL8
|
Extracell. space
|
cytokine
|
7.839
|
9.985
|
↑2.146
|
| |
FABP4
|
Cytoplasm
|
transporter
|
2.351
|
4.506
|
↑2.155
|
|
Lipid metabolism
|
APOE
|
Extracell. space
|
transporter
|
2.591
|
4.958
|
↑2.367
|
| |
PLIN2
|
Plasma memb.
|
other
|
3.725
|
5.772
|
↑2.047
|
| |
RAB20
|
Cytoplasm
|
enzyme
|
2.489
|
4.925
|
↑2.436
|
| |
FAM177B
|
Unknown
|
other
|
5.064
|
7.125
|
↑2.061
|
| |
SELM
|
Cytoplasm
|
other
|
-2.23
|
2.531
|
↑4.761
|
| |
PSMA8
|
Cytoplasm
|
peptidase
|
-2.494
|
3.212
|
↑5.706
|
| |
MSC
|
Cytoplasm
|
transcription regulator
|
3.17
|
5.49
|
↑2.32
|
| |
MRPL44
|
Cytoplasm
|
enzyme
|
2.775
|
-1.356
|
↓4.131
|
|
Miscelleaneous
|
CHMP5
|
Cytoplasm
|
other
|
1.525
|
-2.189
|
↓3.714
|
| |
RORA
|
Nucleus
|
ligand-depend. nuclear recept.
|
-6.756
|
7.147
|
↑13.903
|
| |
ZFP36L1
|
Nucleus
|
transcription regulator
|
3.815
|
6.842
|
↑3.027
|
| |
ZNF573
|
Nucleus
|
other
|
1.412
|
-3.322
|
↓4.734
|
| |
SLC22A6
|
Plasma memb.
|
transporter
|
2.097
|
-2.146
|
↓4.243
|
| |
CDH2
|
Plasma memb.
|
other
|
-1.626
|
-3.634
|
↓2.007
|
| |
KIAA1279
|
Unknown
|
enzyme
|
7.811
|
12.888
|
↑5.077
|
| |
SPATA6
|
Unknown
|
other
|
-2.473
|
19.906
|
↑22.379
|
| |
PSD4
|
Unknown
|
other
|
2.197
|
-2.149
|
↓4.346
|
- 1Fold change of expressed THP-1 genes in response to C. burnetii infection under mock treated condition.
- 2Fold change of expressed THP-1 genes in response to C. burnetii infection under CAM treated condition.
- 3Fold change difference increase (↑) or decrease (↓) between 1 and 2.
