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Table 1 Differentially expressed host genes modulated by C. burnetii protein synthesis.

From: Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection

Cellular Function Gene Symbol Cellular location Predicted Function(s) -CAM1 +CAM2 FD3
  CTSB Cytoplasm peptidase 3.102 6.565 ↑3.463
Apoptosis CTSL1 Cytoplasm peptidase 3.173 6.914 ↑3.741
  BCL3 Nucleus transcription regulator 3.103 5.673 ↑2.57
  C11ORF82 Cytoplasm other -1.849 -4.912 ↓3.062
Cell proliferation SOX11 Nucleus transcription regulator 3.127 -2.915 ↓6.042
  HELLS Nucleus enzyme -1.551 -4.653 ↓3.101
  PGR Nucleus ligand-depend. nuclear recept. -1.539 -6.853 ↓5.313
  ITK Cytoplasm kinase 2.752 -2.46 ↓5.212
Cell signaling DUSP9 Nucleus phosphatase -2.04 -4.388 ↓2.348
  SKP2 Nucleus other 1.581 -2.627 ↓4.208
  MTSS1 Cytoplasm other 4.389 6.986 ↑2.597
Cytoskeleton ANLN Cytoplasm other -1.943 -4.679 ↓2.735
  SMTN Extracell. space other -3.319 4.006 ↑7.325
  PLEKHO1 Plasma memb. other 2.162 5.396 ↑3.234
  SPP1 Extracell. space cytokine 3.351 6.733 ↑3.382
Immune response CCL2 Extracell. space cytokine 5.053 7.451 ↑2.398
  CXCL1 Extracell. space cytokine 5.221 7.275 ↑2.054
  IL8 Extracell. space cytokine 7.839 9.985 ↑2.146
  FABP4 Cytoplasm transporter 2.351 4.506 ↑2.155
Lipid metabolism APOE Extracell. space transporter 2.591 4.958 ↑2.367
  PLIN2 Plasma memb. other 3.725 5.772 ↑2.047
  RAB20 Cytoplasm enzyme 2.489 4.925 ↑2.436
  FAM177B Unknown other 5.064 7.125 ↑2.061
  SELM Cytoplasm other -2.23 2.531 ↑4.761
  PSMA8 Cytoplasm peptidase -2.494 3.212 ↑5.706
  MSC Cytoplasm transcription regulator 3.17 5.49 ↑2.32
  MRPL44 Cytoplasm enzyme 2.775 -1.356 ↓4.131
Miscelleaneous CHMP5 Cytoplasm other 1.525 -2.189 ↓3.714
  RORA Nucleus ligand-depend. nuclear recept. -6.756 7.147 ↑13.903
  ZFP36L1 Nucleus transcription regulator 3.815 6.842 ↑3.027
  ZNF573 Nucleus other 1.412 -3.322 ↓4.734
  SLC22A6 Plasma memb. transporter 2.097 -2.146 ↓4.243
  CDH2 Plasma memb. other -1.626 -3.634 ↓2.007
  KIAA1279 Unknown enzyme 7.811 12.888 ↑5.077
  SPATA6 Unknown other -2.473 19.906 ↑22.379
  PSD4 Unknown other 2.197 -2.149 ↓4.346
  1. 1Fold change of expressed THP-1 genes in response to C. burnetii infection under mock treated condition.
  2. 2Fold change of expressed THP-1 genes in response to C. burnetii infection under CAM treated condition.
  3. 3Fold change difference increase (↑) or decrease (↓) between 1 and 2.